Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research

Dementia and cancer are becoming increasingly common in Western countries. In the last two decades, research has focused on Alzheimer’s disease (AD) and cancers, particularly, breast cancer (BC) and prostate cancer (PC), has been substantially funded both in Europe and worldwide.

While the results of scientific research have contributed to improving our understanding of disease etiopathology, still the prevalence of chronic degenerative conditions are still very high in the whole world. By definition, there is the perfect model. In particular, the animal model of AD, BC, and the PC has been and still is traditionally used in basic research / fundamental, translational and preclinical to study human disease mechanisms, identifying new therapeutic targets and develop new drugs

However, inadequate animal models of several important features of the human disease; Therefore, they often can not pave the way for the development of effective drugs in human patients. The emergence of new tools and models of technology in the life sciences, and the growing need for a multidisciplinary approach has prompted many interdisciplinary research initiatives. With substantial funds invested in biomedical research, it is becoming necessary to define and implement indicators to monitor contributions to innovation and impact of funded research.

Here, we discuss some of the issues underlying the failure of translation in AD, BC, and research PCs, and illustrates how the indicators can be applied to the output size and the impact of the retrospective funded biomedical research.
Disease coronavirus 19 (COVID-19) has dramatically changed daily life, including the field of research of the disease (AD) Alzheimer’s. This perspective article discusses some of the ways in which COVID-19 has impacted the field, anticipating some long-lasting effects, and explore strategies to address the needs of current and future. Areas of impact include the integrity of the study, regulatory issues and industry, and the involvement of the participants.

The proposed strategy to address these challenges include the analytical method to handle large degree lost data and development, user-friendly, means of data collection and remote patient-centered assessments. We also highlight the importance of maintaining the welfare of participants as a first priority and constant.

 Alzheimer's Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research
Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research

Synaptosome as a tool in the study of Alzheimer’s disease

synaptic dysfunction is an integral feature of the disease (AD) pathophysiology of Alzheimer’s. In fact, the prodromal manifestations of structural and functional deficits in synaptic much before the appearance of overt disease indicates that pathological hallmarks of AD may be regarded as a degenerative disorder of synapses.

Some research instruments and techniques have allowed us to study synaptic function and plasticity and their changes in pathological conditions, such as AD. One such tool is the biochemical preparation isolated from apart and resealed synaptic terminal, the “synaptosomes”. Due to the preservation of many physiological processes such as metabolism and enzymatic activity, synaptosomes has proven to be an ex vivo model of system is needed for the study of synaptic physiology either when isolated from fresh or cryopreserved tissue, and from animal or human post-mortem tissue.

Total RNA - Alzheimer's Disease: Brain

R1236035Alz-50 50 ug
EUR 460

Total RNA - Alzheimer's Disease: Frontal Lobe

R1236051Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Parietal Lobe

R1236066Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Temporal Lobe

R1236078Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Occipital Lobe

R1236062Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Corpus Callosum

R1236045Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Precentral Gyrus

R1236073Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Postcentral Gyrus

R1236072Alz-10 10 ug
EUR 460

Pons (Alzheimer's Disease) Lysate

XBL-10298 0.1 mg
EUR 796.2
Description: Human pons tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pons tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pons tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pons tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Brain, BioGenomics

MBS638606-005mg 0.05mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Brain, BioGenomics

MBS638606-5x005mg 5x0.05mg
EUR 2735

cDNA - Alzheimer's Disease: Brain: Pons

C1236071Alz 40 reactions
EUR 802

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Parietal Lobe, BioGenomics

MBS638699-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Parietal Lobe, BioGenomics

MBS638699-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Temporal Lobe, BioGenomics

MBS638730-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Temporal Lobe, BioGenomics

MBS638730-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Frontal Lobe, BioGenomics

MBS638632-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Frontal Lobe, BioGenomics

MBS638632-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Corpus Callosum, BioGenomics

MBS638674-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Corpus Callosum, BioGenomics

MBS638674-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Occipital Lobe, BioGenomics

MBS638555-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Occipital Lobe, BioGenomics

MBS638555-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Postcentral Gyrus, BioGenomics

MBS638543-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Postcentral Gyrus, BioGenomics

MBS638543-5x001mg 5x0.01mg
EUR 2735

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Precentral Gyrus, BioGenomics

MBS638614-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Precentral Gyrus, BioGenomics

MBS638614-5x001mg 5x0.01mg
EUR 2735

Total Protein - Alzheimer's Disease: Brain

P1236035Alz 1 mg
EUR 542

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain

MBS657525-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain

MBS657525-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)

MBS640843-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)

MBS640843-5x5Sections 5x5Sections
EUR 3170

Total Protein - Alzheimer's Disease: Brain: Amygdala

P1236036Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Thalamus

P1236079Alz 1 mg
EUR 542

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)

MBS640521-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)

MBS640521-5x5Sections 5x5Sections
EUR 2145

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons

T1236071Alz 5 slides
EUR 523

Total Protein - Alzheimer's Disease: Brain: Cerebellum

P1236039Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Hippocampus

P1236052Alz 1 mg
EUR 667

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Thalamus

MBS657447-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Thalamus

MBS657447-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS657576-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS657576-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Cerebellum

MBS657508-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Cerebellum

MBS657508-5x1mg 5x1mg
EUR 3470

Total Protein - Alzheimer's Disease: Brain: Frontal Lobe

P1236051Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Parietal Lobe

P1236066Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Temporal Lobe

P1236078Alz 1 mg
EUR 542

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS657034-1mg 1mg
EUR 920

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS657034-5x1mg 5x1mg
EUR 3920

Total Protein - Alzheimer's Disease: Brain: Occipital Lobe

P1236062Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Corpus Callosum

P1236045Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Precentral Gyrus

P1236073Alz 1 mg
EUR 542

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS657032-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS657032-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe

MBS657046-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe

MBS657046-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe

MBS657343-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe

MBS657343-5x1mg 5x1mg
EUR 3470

Total Protein - Alzheimer's Disease: Brain: Medulla oblongata

P1236057Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Postcentral Gyrus

P1236072Alz 1 mg
EUR 542

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum

MBS657061-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum

MBS657061-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe

MBS657066-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe

MBS657066-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus

MBS657142-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus

MBS657142-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus

MBS657585-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus

MBS657585-5x1mg 5x1mg
EUR 3470

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Pons, BioGenomics

MBS654522-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Pons, BioGenomics

MBS654522-5x005mg 5x0.05mg
EUR 3075

Genomic DNA - Alzheimer's Disease: Brain: Pons, from a single donor

D1236071Alz 50 ug
EUR 562

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Pons, BioGenomics

MBS652281-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Pons, BioGenomics

MBS652281-5x40Tests 5x40Tests
EUR 4250

Tissue, Genomic DNA, Human Disease, Alzheimer's Disease, Alzheimer's Brain, BioGenomics

MBS654298-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease, Alzheimer's Disease, Alzheimer's Brain, BioGenomics

MBS654298-5x005mg 5x0.05mg
EUR 3075

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons

T2236071Alz 5 slides
EUR 262

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 802

Amygdala (Alzheimer's Disease) Lysate

XBL-10274 0.1 mg
EUR 796.2
Description: Human amygdala tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human amygdala tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the amygdala tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The amygdala tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Thalamus (Alzheimer's Disease) Lysate

XBL-10310 0.1 mg
EUR 796.2
Description: Human thalamus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human thalamus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the thalamus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The thalamus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Hippocampus (Alzheimer's Disease) Lysate

XBL-10286 0.1 mg
EUR 922.2
Description: Human hippocamps tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human hippocamps tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the hippocamps tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The hippocamps tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Thalamus

C1236079Alz 40 reactions
EUR 802

Frontal Lobe (Alzheimer's Disease) Lysate

XBL-10282 0.1 mg
EUR 796.2
Description: Human frontal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human frontal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the frontal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The frontal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Serum - Alzheimer's Disease - Human Patient

MBS170478-1Sample 1Sample
EUR 415

Serum - Alzheimer's Disease - Human Patient

MBS170478-5Samples 5Samples
EUR 1540

Serum - Alzheimer's Disease - Human Patient

MBS170478-5x5Samples 5x5Samples
EUR 6720

Parietal Lobe (Alzheimer's Disease) Lysate

XBL-10294 0.1 mg
EUR 796.2
Description: Human parietal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human parietal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the parietal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The parietal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Temporal Lobe (Alzheimer's Disease) Lysate

XBL-10314 0.1 mg
EUR 796.2
Description: Human temporal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human temporal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the temporal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The temporal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Human Alzheimer's Disease Primer Library

HAZD-I 1 set
EUR 657.6

cDNA - Alzheimer's Disease: Brain: Cerebellum

C1236039Alz 40 reactions
EUR 802

Occipital lobe (Alzheimer's Disease) Lysate

XBL-10290 0.1 mg
EUR 796.2
Description: Human occipital lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human occipital lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the occipital lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The occipital lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)

MBS640021-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)

MBS640021-5x5Slides 5x5Slides
EUR 3170

cDNA - Alzheimer's Disease: Brain: Hippocampus

C1236052Alz 40 reactions
EUR 975

Corpus Callosum (Alzheimer's Disease) Lysate

XBL-10278 0.1 mg
EUR 796.2
Description: Human corpus Callosum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human corpus Callosum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the corpus Callosum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The corpus Callosum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Human iPS Cell Line (Alzheimer's Disease)

CSC-00850L One Frozen vial Ask for price

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)

MBS640539-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)

MBS640539-5x5Sections 5x5Sections
EUR 2145

Precentral Gyrus (Alzheimer's Disease) Lysate

XBL-10306 0.1 mg
EUR 796.2
Description: Human precentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human precentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the precentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The precentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Amygdala (Alzheimer's Disease) Membrane Lysate

XBL-10272 0.1 mg
EUR 752.1
Description: Human brain amygdala tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human amygdala tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain amygdala tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain amygdala tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Postcentral Gyrus (Alzheimer's Disease) Lysate

XBL-10302 0.1 mg
EUR 796.2
Description: Human postcentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human postcentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the postcentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The postcentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue II, frontal lobe, temporal lobe, parietal lobe, occipital lobe, pons, thalamus, corpus callosum

MBS639675-5Arrays 5Arrays
EUR 880

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue II, frontal lobe, temporal lobe, parietal lobe, occipital lobe, pons, thalamus, corpus callosum

MBS639675-5x5Arrays 5x5Arrays
EUR 3820

cDNA - Alzheimer's Disease: Brain: Frontal Lobe

C1236051Alz 40 reactions
EUR 802

Hippocampus (Alzheimer's Disease) Membrane Lysate

XBL-10284 0.1 mg
EUR 852.9
Description: Human brain hippocamps tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Alzheimer's Disease: Brain: Parietal Lobe

C1236066Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Temporal Lobe

C1236078Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Occipital Lobe

C1236062Alz 40 reactions
EUR 802

Hippocampus (Alzheimer's Disease) Cytoplasmic Lysate

XBL-10283 0.1 mg
EUR 273.3
Description: Human brain hippocamps tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Precentral Gyrus

C1236073Alz 40 reactions
EUR 802

Frozen Tissue Section - Alzheimer's Disease: Brain

T1236035Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)

MBS640320-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)

MBS640320-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)

MBS640174-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)

MBS640174-5x5Sections 5x5Sections
EUR 3170

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue II, Corpus Callosum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Pons, Temporal Lobe, Thalamus

MBS640559-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue II, Corpus Callosum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Pons, Temporal Lobe, Thalamus

MBS640559-5x5Slides 5x5Slides
EUR 6190

cDNA - Alzheimer's Disease: Brain: Postcentral Gyrus

C1236072Alz 40 reactions
EUR 802

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)

MBS640323-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)

MBS640323-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)

MBS640027-5Sections 5Sections
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)

MBS640027-5x5Sections 5x5Sections
EUR 5155

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS639891-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS639891-5x01mg 5x0.1mg
EUR 2915

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)

MBS640834-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)

MBS640834-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)

MBS640882-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)

MBS640882-5x5Sections 5x5Sections
EUR 2145

Temporal Lobe (Alzheimer's Disease) Membrane Lysate

XBL-10312 0.1 mg
EUR 752.1
Description: Human brain temporal lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human temporal lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain temporal lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain temporal lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS639767-01mg 0.1mg
EUR 770

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS639767-5x01mg 5x0.1mg
EUR 3250

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)

MBS640497-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)

MBS640497-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)

MBS640635-5Sections 5Sections
EUR 985

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)

MBS640635-5x5Sections 5x5Sections
EUR 4280

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)

MBS640297-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)

MBS640297-5x5Sections 5x5Sections
EUR 3170

Non-Ab Component of Alzheimer's Disease Amyloid

5-01639 4 x 1mg Ask for price

Non-Ab Component of Alzheimer's Disease Amyloid

SP-89317-1 1 mg
EUR 343.2

Non-Ab Component of Alzheimer's Disease Amyloid

MBS8246838-10mg 10mg
EUR 1190

Non-Ab Component of Alzheimer's Disease Amyloid

MBS8246838-1mg 1mg
EUR 380

Non-Ab Component of Alzheimer's Disease Amyloid

MBS8246838-5mg 5mg
EUR 825

Non-Ab Component of Alzheimer's Disease Amyloid

MBS8246838-5x10mg 5x10mg
EUR 5260

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)

MBS640325-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)

MBS640325-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)

MBS640199-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)

MBS640199-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)

MBS640659-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)

MBS640659-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)

MBS640253-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)

MBS640253-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)

MBS640156-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)

MBS640156-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)

MBS639971-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)

MBS639971-5x5Slides 5x5Slides
EUR 5155

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS639875-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS639875-5x01mg 5x0.1mg
EUR 2915

This model system has been very successful in the case of post-mortem tissue because of their relative accessibility to acute brain slices or culture. The current review usage details synaptosomes in AD research and its potential as a valuable tool in furthering our understanding of the pathogenesis and in designing and testing therapeutic strategies for this disease.