Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research

Dementia and cancer are becoming increasingly common in Western countries. In the last two decades, research has focused on Alzheimer’s disease (AD) and cancers, particularly, breast cancer (BC) and prostate cancer (PC), has been substantially funded both in Europe and worldwide.

While the results of scientific research have contributed to improving our understanding of disease etiopathology, still the prevalence of chronic degenerative conditions are still very high in the whole world. By definition, there is the perfect model. In particular, the animal model of AD, BC, and the PC has been and still is traditionally used in basic research / fundamental, translational and preclinical to study human disease mechanisms, identifying new therapeutic targets and develop new drugs

However, inadequate animal models of several important features of the human disease; Therefore, they often can not pave the way for the development of effective drugs in human patients. The emergence of new tools and models of technology in the life sciences, and the growing need for a multidisciplinary approach has prompted many interdisciplinary research initiatives. With substantial funds invested in biomedical research, it is becoming necessary to define and implement indicators to monitor contributions to innovation and impact of funded research.

Here, we discuss some of the issues underlying the failure of translation in AD, BC, and research PCs, and illustrates how the indicators can be applied to the output size and the impact of the retrospective funded biomedical research.
Disease coronavirus 19 (COVID-19) has dramatically changed daily life, including the field of research of the disease (AD) Alzheimer’s. This perspective article discusses some of the ways in which COVID-19 has impacted the field, anticipating some long-lasting effects, and explore strategies to address the needs of current and future. Areas of impact include the integrity of the study, regulatory issues and industry, and the involvement of the participants.

The proposed strategy to address these challenges include the analytical method to handle large degree lost data and development, user-friendly, means of data collection and remote patient-centered assessments. We also highlight the importance of maintaining the welfare of participants as a first priority and constant.

 Alzheimer's Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research
Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research

Synaptosome as a tool in the study of Alzheimer’s disease

synaptic dysfunction is an integral feature of the disease (AD) pathophysiology of Alzheimer’s. In fact, the prodromal manifestations of structural and functional deficits in synaptic much before the appearance of overt disease indicates that pathological hallmarks of AD may be regarded as a degenerative disorder of synapses.

Some research instruments and techniques have allowed us to study synaptic function and plasticity and their changes in pathological conditions, such as AD. One such tool is the biochemical preparation isolated from apart and resealed synaptic terminal, the “synaptosomes”. Due to the preservation of many physiological processes such as metabolism and enzymatic activity, synaptosomes has proven to be an ex vivo model of system is needed for the study of synaptic physiology either when isolated from fresh or cryopreserved tissue, and from animal or human post-mortem tissue.

Total RNA - Alzheimer's Disease: Occipital Lobe

R1236062Alz-10 10 ug
EUR 421.2

Total RNA - Alzheimer's Disease: Corpus Callosum

R1236045Alz-10 10 ug
EUR 421.2

Total RNA - Alzheimer's Disease: Precentral Gyrus

R1236073Alz-10 10 ug
EUR 421.2

Total RNA - Alzheimer's Disease: Postcentral Gyrus

R1236072Alz-10 10 ug
EUR 421.2

Pons (Alzheimer's Disease) Lysate

XBL-10298 0.1 mg
EUR 796.2
Description: Human pons tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pons tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pons tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pons tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Pons

C1236071Alz 40 reactions
EUR 729

Total Protein - Alzheimer's Disease: Brain

P1236035Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Amygdala

P1236036Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Thalamus

P1236079Alz 1 mg
EUR 471

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons

T1236071Alz 5 slides
EUR 475

Total Protein - Alzheimer's Disease: Brain: Cerebellum

P1236039Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Hippocampus

P1236052Alz 1 mg
EUR 580

Total Protein - Alzheimer's Disease: Brain: Frontal Lobe

P1236051Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Parietal Lobe

P1236066Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Temporal Lobe

P1236078Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Occipital Lobe

P1236062Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Corpus Callosum

P1236045Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Precentral Gyrus

P1236073Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Medulla oblongata

P1236057Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Postcentral Gyrus

P1236072Alz 1 mg
EUR 471

Genomic DNA - Alzheimer's Disease: Brain: Pons, from a single donor

D1236071Alz 50 ug
EUR 489

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 729

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons

T2236071Alz 5 slides
EUR 238

Amygdala (Alzheimer's Disease) Lysate

XBL-10274 0.1 mg
EUR 796.2
Description: Human amygdala tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human amygdala tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the amygdala tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The amygdala tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Thalamus (Alzheimer's Disease) Lysate

XBL-10310 0.1 mg
EUR 796.2
Description: Human thalamus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human thalamus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the thalamus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The thalamus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Hippocampus (Alzheimer's Disease) Lysate

XBL-10286 0.1 mg
EUR 922.2
Description: Human hippocamps tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human hippocamps tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the hippocamps tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The hippocamps tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Thalamus

C1236079Alz 40 reactions
EUR 729

Frontal Lobe (Alzheimer's Disease) Lysate

XBL-10282 0.1 mg
EUR 796.2
Description: Human frontal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human frontal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the frontal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The frontal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Human Alzheimer's Disease Primer Library

HAZD-I 1 set
EUR 657.6

Parietal Lobe (Alzheimer's Disease) Lysate

XBL-10294 0.1 mg
EUR 796.2
Description: Human parietal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human parietal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the parietal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The parietal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Temporal Lobe (Alzheimer's Disease) Lysate

XBL-10314 0.1 mg
EUR 796.2
Description: Human temporal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human temporal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the temporal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The temporal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Cerebellum

C1236039Alz 40 reactions
EUR 729

Occipital lobe (Alzheimer's Disease) Lysate

XBL-10290 0.1 mg
EUR 796.2
Description: Human occipital lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human occipital lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the occipital lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The occipital lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Hippocampus

C1236052Alz 40 reactions
EUR 886

Corpus Callosum (Alzheimer's Disease) Lysate

XBL-10278 0.1 mg
EUR 796.2
Description: Human corpus Callosum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human corpus Callosum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the corpus Callosum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The corpus Callosum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Precentral Gyrus (Alzheimer's Disease) Lysate

XBL-10306 0.1 mg
EUR 796.2
Description: Human precentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human precentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the precentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The precentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Amygdala (Alzheimer's Disease) Membrane Lysate

XBL-10272 0.1 mg
EUR 752.1
Description: Human brain amygdala tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human amygdala tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain amygdala tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain amygdala tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Postcentral Gyrus (Alzheimer's Disease) Lysate

XBL-10302 0.1 mg
EUR 796.2
Description: Human postcentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human postcentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the postcentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The postcentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Frontal Lobe

C1236051Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Parietal Lobe

C1236066Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Temporal Lobe

C1236078Alz 40 reactions
EUR 729

Hippocampus (Alzheimer's Disease) Membrane Lysate

XBL-10284 0.1 mg
EUR 852.9
Description: Human brain hippocamps tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Alzheimer's Disease: Brain: Occipital Lobe

C1236062Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Precentral Gyrus

C1236073Alz 40 reactions
EUR 729

Frozen Tissue Section - Alzheimer's Disease: Brain

T1236035Alz 5 slides
EUR 475

Hippocampus (Alzheimer's Disease) Cytoplasmic Lysate

XBL-10283 0.1 mg
EUR 273.3
Description: Human brain hippocamps tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Postcentral Gyrus

C1236072Alz 40 reactions
EUR 729

Temporal Lobe (Alzheimer's Disease) Membrane Lysate

XBL-10312 0.1 mg
EUR 752.1
Description: Human brain temporal lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human temporal lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain temporal lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain temporal lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Non-Ab Component of Alzheimer's Disease Amyloid

5-01639 4 x 1mg Ask for price

Non-Ab Component of Alzheimer's Disease Amyloid

SP-89317-1 1 mg
EUR 343.2

Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala

T1236036Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus

T1236079Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary

T1236068Alz 5 slides
EUR 883

Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T1236039Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus

T1236052Alz 5 slides
EUR 883

Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T2236039Alz 5 slides
EUR 238

Genomic DNA - Alzheimer's Disease: Brain, from a single donor

D1236035Alz 50 ug
EUR 489

Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe

T1236051Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe

T1236066Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Temporal Lobe

T1236078Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Occipital Lobe

T1236062Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum

T1236045Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus

T1236073Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T1236057Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus

T1236072Alz 5 slides
EUR 475

Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T2236057Alz 5 slides
EUR 475

Genomic DNA - Alzheimer's Disease: Brain: Thalamus, from a single donor

D1236079Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Cerebellum, from a single donor

D1236039Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Frontal Lobe, from a single donor

D1236051Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Parietal Lobe, from a single donor

D1236066Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Temporal Lobe, from a single donor

D1236078Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Occipital Lobe, from a single donor

D1236062Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Precentral Gyrus , from a single donor

D1236073Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Corpus Callosum, from a single donor

D1236045Alz 50 ug
EUR 489

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 7 different tissues

T6236444Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T6236445Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T6236446Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T6236564Alz 5 slides
EUR 1135

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 8 different tissues

T8236444Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T8236445Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T8236564Alz 5 slides
EUR 648

Genomic DNA - Alzheimer's Disease: Brain: Postcentral Gyrus , from a single donor

D1236072Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Medulla oblongata, from a single donor

D1236057Alz 50 ug
EUR 489

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T8236446Alz 5 slides
EUR 648

Membrane Protein - Alzheimer's Disease:Brain: Amygdala

P3236036Alz 0.1 mg
EUR 410

Membrane Protein - Alzheimer's Disease:Brain: Hippocampus

P3236052Alz 0.1 mg
EUR 508

Membrane Protein - Alzheimer's Disease:Brain: Temporal Lobe

P3236078Alz 0.1 mg
EUR 410

Total Protein - Parkinson's Disease: Brain: Pons

P1236071Par 1 mg
EUR 471

Paraffin Tissue Section - Alzheimers Disease: Brain

T2236035Alz 5 slides
EUR 238

Alzheimers Disease gamma-Secretase Detection Set

PSI-1820 1 Set
EUR 752.1
Description: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by three enzymes (TACE, BACE/BACE2 and γ-secretase) at three distinct sites (α, β and γ respectively). The γ-secretase complex is a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer and is composed of the proteins APH1, nicastrin, PEN2 and presenilin1. Its cleavage of APP results in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ (from the β and γ cleavage site). APH1 was initially identified as a component of the Notch pathway and exists in at least three distinct isoforms with APH1a as the principal isoform present in the γ-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Besides acting as a critical component of the γ-secretase complex, nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of nicastrin expression results in mouse embryonic lethality. Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease.;;For images please see PDF data sheet

Total Protein - Multiple Sclerosis Disease: Brain: Pons

P1236071Msc 1 mg
EUR 471

Alzheimers Disease B-Amyloid Protein Detection Set

PSI-1812 1 Set
EUR 752.1
Description: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The βamyloid protein precursor (APP) is cleaved by one of two βsecretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for βsecretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer’s disease patients’ brains. BACE was identified by several groups independently and designated β-site APP cleaving enzyme (BACE) . BACE is a transmembrane aspartic protease and co-localizes with APP. BACE2 also cleaves APP at β-site and at a different site within Aβ. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.;;For images please see PDF data sheet

Paraffin Tissue Section - Alzheimers Disease: Brain: Amygdala

T2236036Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus

T2236079Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Frontal Lobe

T2236051Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus

T2236052Alz 5 slides
EUR 758

Paraffin Tissue Section - Alzheimers Disease: Brain: Parietal Lobe

T2236066Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Temporal Lobe

T2236078Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Corpus Callosum

T2236045Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Occipital Lobe

T2236062Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Precentral Gyrus (Movement)

T2236073Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Postcentral Gyrus (Sensation)

T2236072Alz 5 slides
EUR 238

Total RNA - Diabetic Disease: Colon

R1236090Dia-50 50 ug
EUR 421.2

Total RNA - Diabetic Disease: Stomach

R1236248Dia-50 50 ug
EUR 421.2

Total RNA - Diabetic Disease: Pancreas

R1236188Dia-50 50 ug
EUR 421.2

Total RNA - Diabetic Disease: Esophagus

R1236106Dia-50 50 ug
EUR 421.2

Total RNA - Congenital heart disease: Heart

R1236122Hd-3 50 ug
EUR 421.2

Total Protein - Parkinson's Disease: Brain

P1236035Par 1 mg
EUR 471

Total RNA - Human Adult Normal Tissue: Brain: Pons

R1234071-10 10 ug
EUR 183

Frozen Tissue Section - Parkinson's Disease: Brain: Pons

T1236071Par 5 slides
EUR 475

Total Protein - Congenital heart disease: Heart

P1236122Hd-3 1 mg
EUR 471

Paraffin Tissue Section - Parkinson's Disease: Brain: Pons

T2236071Par 5 slides
EUR 238

Total Protein - Multiple Sclerosis Disease: Brain

P1236035Msc 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Amygdala

P1236036Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Thalamus

P1236079Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Cerebellum

P1236039Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Frontal Lobe

P1236051Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Parietal Lobe

P1236066Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Temporal Lobe

P1236078Par 1 mg
EUR 471

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Pons

T1236071Msc 5 slides
EUR 475

Total Protein - Parkinson's Disease: Brain: Occipital Lobe

P1236062Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Corpus Callosum

P1236045Par 1 mg
EUR 471

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Pons

T2236071Msc 5 slides
EUR 238

Total Protein - Parkinson's Disease: Brain: Precentral Gyrus

P1236073Par 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Amygdala

P1236036Msc 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Medulla oblongata

P1236057Par 1 mg
EUR 471

Total Protein - Parkinson's Disease: Brain: Postcentral Gyrus

P1236072Par 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Thalamus

P1236079Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Cerebellum

P1236039Msc 1 mg
EUR 471

Genomic DNA - Parkinson's Disease: Brain: Pons, from a single donor

D1236071Par 50 ug
EUR 489

Total Protein - Multiple Sclerosis Disease: Brain: Frontal Lobe

P1236051Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Parietal Lobe

P1236066Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Temporal Lobe

P1236078Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Occipital Lobe

P1236062Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Corpus Callosum

P1236045Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Medulla oblongata

P1236057Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Postcentral Gyrus

P1236072Msc 1 mg
EUR 471

Total Protein - Multiple Sclerosis Disease: Brain: Precentral Gyrus

P1236073Msc 1 mg
EUR 471

Genomic DNA - Multiple Sclerosis Disease: Brain: Pons, from a single donor

D1236071Msc 50 ug
EUR 489

Crohn's Disease Exosome RNA

P241-CR - Ask for price

Total Protein - Human Diabetic Diseased Tissue: Lung

P1236152Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Skin

P1236218Dia 1 mg
EUR 471

Fetal Alzheimer antigen (FALZ) polyclonal antibody

ABP-PAB-02251 100 ug Ask for price

Total Protein - Human Diabetic Diseased Tissue: Brain

P1236035Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Colon

P1236090Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Heart

P1236122Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Liver

P1236149Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Kidney

P1236142Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Spleen

P1236246Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Adrenal

P1236004Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Stomach

P1236248Dia 1 mg
EUR 471

Total Protein - Progressive Supranuclear Palsy: Brain: Pons

P1236071PSP 1 mg
EUR 580

Total Protein - Human Diabetic Diseased Tissue: Pancreas

P1236188Dia 1 mg
EUR 471

Rat Alzheimer associated neuronal thread protein ELISA kit

E02A0224-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Alzheimer associated neuronal thread protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alzheimer associated neuronal thread protein ELISA kit

E02A0224-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Alzheimer associated neuronal thread protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alzheimer associated neuronal thread protein ELISA kit

E02A0224-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Alzheimer associated neuronal thread protein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

This model system has been very successful in the case of post-mortem tissue because of their relative accessibility to acute brain slices or culture. The current review usage details synaptosomes in AD research and its potential as a valuable tool in furthering our understanding of the pathogenesis and in designing and testing therapeutic strategies for this disease.