Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research

Background: Growing awareness of Alzheimer’s disease (AD) has boosted demand for quick and effective way to screen for memory loss and cognitive decline in a large number of individuals in society. Periodic Memory Screening Day events provide free, brief cognitive screening is intended for those 65 years and older, and can serve as an opportunity for participants to measure attitudes toward AD research and recruit them into research projects ongoing.


Methods: Over 6 one-day event in two years, more than 574 people individually filtered using a Moca and assignment story recall (immediate and delayed), are given feedback on their performance, and introduced the AD research and opportunities to participate.


Results: Screening classified 297 individuals (52.0%) as having “No Decline,” 192 (33.6%) as “The possibility of a decrease,” and 82 (14.4%) as “Likely decline.” Those with a “decline Likely” older and less educated, have more memory concerns, are more likely to be male, and less likely to have a positive family history of dementia compared with “No Decline.” subsequent validation of a screening procedure to full clinical evaluation revealed 72% classification accuracy with a leaning toward more-calling Possible and Likely reduction and thus guiding people questioned for a more thorough evaluation.

Of those screened, 378 (66%) agreed to additional research and approve research recorded in the registry, and the majority (70-85%) of approving reported they agreed to research the various AD procedures including lumbar puncture, MRI, and autopsy. Overall, 19.1% of those screened met the inclusion criteria for the ongoing study and successfully recruited to the study of AD.


Conclusion: Conducting the public memory is concentrated several screening events every year to help meet the public demand for a brief assessment of memory concerns and can be relatively effective recruitment strategies and efficient for AD research.

 Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research
Community memory screening as a strategy for recruiting older adults into Alzheimer’s disease research

Attractive New Investigator Research into Alzheimer’s disease: Results from Increased Funding and Outreach

Since 2015, the National Institute on Aging (NIA), the National Institutes of Health (NIH), has experienced a significant increase in funding for Alzheimer’s disease and dementia related to Alzheimer’s disease (AD / ADRD). This analysis assessed the impact of these funds on workforce expansion AD / ADRD. NIA was given 860 awards to 695 AD / grantee ADRD R01 during the fiscal year 2015-2018. Twenty-nine percent of recipients that are new or early stage researchers, while 38% are new to the field of AD research / ADRD (NTF).

NTFS Among these, 59% established researchers, namely, the experts at NIH funding in other disciplines but only for AD / research ADRD. The next award is analyzed to determine the focus of their research is based on the International Alzheimer’s Disease Research Portfolio (IADRP) category. Forty-six percent focused on Molecular Pathogenesis and Physiology. Other IADRP categories, including Diagnosis, Assessment, and Monitoring Disease and Translational Research and Clinical Intervention, representing 5% -15% of the award.

Total RNA - Alzheimer's Disease: Parietal Lobe

R1236066Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Temporal Lobe

R1236078Alz-10 10 ug
EUR 460

Total Protein - Parkinson's Disease: Brain: Occipital Lobe

P1236062Par 1 mg
EUR 542

Total Protein - Multiple Sclerosis Disease: Brain: Occipital Lobe

P1236062Msc 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Frontal Lobe

P1236051Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Parietal Lobe

P1236066Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Temporal Lobe

P1236078Alz 1 mg
EUR 542

Total RNA - Alzheimer's Disease: Pons

R1236071Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Brain

R1236035Alz-50 50 ug
EUR 460

Total RNA - Alzheimer's Disease: Corpus Callosum

R1236045Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Precentral Gyrus

R1236073Alz-10 10 ug
EUR 460

Total RNA - Alzheimer's Disease: Postcentral Gyrus

R1236072Alz-10 10 ug
EUR 460

Frontal Lobe (Alzheimer's Disease) Lysate

XBL-10282 0.1 mg
EUR 796.2
Description: Human frontal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human frontal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the frontal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The frontal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Parietal Lobe (Alzheimer's Disease) Lysate

XBL-10294 0.1 mg
EUR 796.2
Description: Human parietal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human parietal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the parietal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The parietal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Temporal Lobe (Alzheimer's Disease) Lysate

XBL-10314 0.1 mg
EUR 796.2
Description: Human temporal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human temporal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the temporal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The temporal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total Protein - Alzheimer's Disease: Brain

P1236035Alz 1 mg
EUR 542

cDNA - Alzheimer's Disease: Brain: Frontal Lobe

C1236051Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Parietal Lobe

C1236066Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Temporal Lobe

C1236078Alz 40 reactions
EUR 802

Total Protein - Alzheimer's Disease: Brain: Pons

P1236071Alz 1 mg
EUR 542

Temporal Lobe (Alzheimer's Disease) Membrane Lysate

XBL-10312 0.1 mg
EUR 752.1
Description: Human brain temporal lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human temporal lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain temporal lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain temporal lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Frozen Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T1236062Par 5 slides
EUR 523

Total Protein - Alzheimer's Disease: Brain: Amygdala

P1236036Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Thalamus

P1236079Alz 1 mg
EUR 542

Total RNA - Human Adult Normal Tissue: Brain: Occipital Lobe

R1234062-50 50 ug
EUR 221

Paraffin Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T2236062Par 5 slides
EUR 262

Total Protein - Alzheimer's Disease: Brain: Cerebellum

P1236039Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Hippocampus

P1236052Alz 1 mg
EUR 667

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe

T1236062Msc 5 slides
EUR 523

Total Protein - Alzheimer's Disease: Brain: Corpus Callosum

P1236045Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Precentral Gyrus

P1236073Alz 1 mg
EUR 542

Total Protein - Dementia: Brain: Occipital Lobe

P1236062Dem 1 mg
EUR 542

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe

T2236062Msc 5 slides
EUR 262

Total Protein - Alzheimer's Disease: Brain: Medulla oblongata

P1236057Alz 1 mg
EUR 542

Total Protein - Alzheimer's Disease: Brain: Postcentral Gyrus

P1236072Alz 1 mg
EUR 542

Total Protein - Depression: Brain: Occipital Lobe

P1236062Dep 1 mg
EUR 542

Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe

T1236051Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe

T1236066Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Temporal Lobe

T1236078Alz 5 slides
EUR 523

Genomic DNA - Parkinson's Disease: Brain: Occipital Lobe, from a single donor

D1236062Par 50 ug
EUR 562

Total RNA - Human Adult Normal Tissue 5 Donor Pool: Brain: Occipital Lobe

R1234062-P 50 ug
EUR 443

Genomic DNA - Multiple Sclerosis Disease: Brain: Occipital Lobe, from a single donor

D1236062Msc 50 ug
EUR 562

Genomic DNA - Alzheimer's Disease: Brain: Frontal Lobe, from a single donor

D1236051Alz 50 ug
EUR 562

Genomic DNA - Alzheimer's Disease: Brain: Parietal Lobe, from a single donor

D1236066Alz 50 ug
EUR 562

Genomic DNA - Alzheimer's Disease: Brain: Temporal Lobe, from a single donor

D1236078Alz 50 ug
EUR 562

Membrane Protein - Alzheimer's Disease:Brain: Temporal Lobe

P3236078Alz 0.1 mg
EUR 472

Total Protein - Human Adult Normal Tissue: Brain: Occipital Lobe

P1234062 1 mg
EUR 216

Total Protein - Progressive Supranuclear Palsy: Brain: Occipital Lobe

P1236062PSP 1 mg
EUR 667

Occipital Lobe

TB19005 0.1 gm
EUR 475.2

Occipital Lobe

TB19012 5 Slides
EUR 506.4

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 802

Pons (Alzheimer's Disease) Lysate

XBL-10298 0.1 mg
EUR 796.2
Description: Human pons tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pons tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pons tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pons tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Amygdala (Alzheimer's Disease) Lysate

XBL-10274 0.1 mg
EUR 796.2
Description: Human amygdala tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human amygdala tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the amygdala tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The amygdala tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Thalamus (Alzheimer's Disease) Lysate

XBL-10310 0.1 mg
EUR 796.2
Description: Human thalamus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human thalamus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the thalamus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The thalamus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Hippocampus (Alzheimer's Disease) Lysate

XBL-10286 0.1 mg
EUR 922.2
Description: Human hippocamps tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human hippocamps tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the hippocamps tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The hippocamps tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Pons

C1236071Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 802

cDNA - Alzheimer's Disease: Brain: Thalamus

C1236079Alz 40 reactions
EUR 802

Human Alzheimer's Disease Primer Library

HAZD-I 1 set
EUR 657.6

cDNA - Alzheimer's Disease: Brain: Cerebellum

C1236039Alz 40 reactions
EUR 802

Human iPS Cell Line (Alzheimer's Disease)

CSC-00850L One Frozen vial Ask for price

cDNA - Alzheimer's Disease: Brain: Hippocampus

C1236052Alz 40 reactions
EUR 975

Corpus Callosum (Alzheimer's Disease) Lysate

XBL-10278 0.1 mg
EUR 796.2
Description: Human corpus Callosum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human corpus Callosum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the corpus Callosum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The corpus Callosum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Precentral Gyrus (Alzheimer's Disease) Lysate

XBL-10306 0.1 mg
EUR 796.2
Description: Human precentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human precentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the precentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The precentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Amygdala (Alzheimer's Disease) Membrane Lysate

XBL-10272 0.1 mg
EUR 752.1
Description: Human brain amygdala tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human amygdala tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain amygdala tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain amygdala tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Postcentral Gyrus (Alzheimer's Disease) Lysate

XBL-10302 0.1 mg
EUR 796.2
Description: Human postcentral gyrus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human postcentral gyrus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the postcentral gyrus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The postcentral gyrus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Paraffin Tissue Section - Alzheimers Disease: Brain: Frontal Lobe

T2236051Alz 5 slides
EUR 262

Occipital Lobe Membrane Lysate

XBL-10184 0.1 mg
EUR 619.8
Description: Human brain occipital lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human occipital lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain occipital lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain occipital lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Paraffin Tissue Section - Alzheimers Disease: Brain: Parietal Lobe

T2236066Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Temporal Lobe

T2236078Alz 5 slides
EUR 262

Hippocampus (Alzheimer's Disease) Membrane Lysate

XBL-10284 0.1 mg
EUR 852.9
Description: Human brain hippocamps tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Alzheimer's Disease: Brain: Precentral Gyrus

C1236073Alz 40 reactions
EUR 802

Frozen Tissue Section - Alzheimer's Disease: Brain

T1236035Alz 5 slides
EUR 523

Hippocampus (Alzheimer's Disease) Cytoplasmic Lysate

XBL-10283 0.1 mg
EUR 273.3
Description: Human brain hippocamps tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Postcentral Gyrus

C1236072Alz 40 reactions
EUR 802

Non-Ab Component of Alzheimer's Disease Amyloid

5-01639 4 x 1mg Ask for price

Non-Ab Component of Alzheimer's Disease Amyloid

SP-89317-1 1 mg
EUR 343.2

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons

T1236071Alz 5 slides
EUR 523

OCPB00101-100UG - Occipital Lobe Lysate

OCPB00101-100UG 0.1mg
EUR 139

OCPB00515-100UG - Occipital lobe Lysate

OCPB00515-100UG 0.1mg
EUR 739

Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala

T1236036Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus

T1236079Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary

T1236068Alz 5 slides
EUR 971

Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T1236039Alz 5 slides
EUR 523

Non-Ab Component of Alzheimer's Disease Amyloid Peptide

abx266991-1ml 1 ml
EUR 925

Non-Ab Component of Alzheimer's Disease Amyloid Peptide

abx266991-200l 200 µl
EUR 375

Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus

T1236052Alz 5 slides
EUR 971

Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T2236039Alz 5 slides
EUR 262

Genomic DNA - Alzheimer's Disease: Brain, from a single donor

D1236035Alz 50 ug
EUR 562

Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum

T1236045Alz 5 slides
EUR 523

OCPB00495-100UG - Occipital Lobe Membrane Lysate

OCPB00495-100UG 0.1mg
EUR 559

Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus

T1236073Alz 5 slides
EUR 523

Genomic DNA - Alzheimer's Disease: Brain: Pons, from a single donor

D1236071Alz 50 ug
EUR 562

Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T1236057Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus

T1236072Alz 5 slides
EUR 523

Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T2236057Alz 5 slides
EUR 523

HighQC™ Human IPSC From Fibroblast-Familial Alzheimer's Disease

ABC-SC2075 1 vial Ask for price
Description: Cell Type: iPSC; Primary Tissue: Fibroblast; Reprogramming Method: Episomal Plasmid; Disease: Familial Alzheimer's Disease; Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

Genomic DNA - Alzheimer's Disease: Brain: Thalamus, from a single donor

D1236079Alz 50 ug
EUR 562

Human Brain Occipital Lobe Lysate Membrane Fraction

IHUBROCCTLM100UG each
EUR 870
Description: Human Brain Occipital Lobe Lysate Membrane Fraction

Frozen Tissue Section - Dementia: Brain: Occipital Lobe

T1236062Dem 5 slides
EUR 523

Genomic DNA - Alzheimer's Disease: Brain: Cerebellum, from a single donor

D1236039Alz 50 ug
EUR 562

Paraffin Tissue Section - Dementia: Brain: Occipital Lobe

T2236062Dem 5 slides
EUR 262

Frozen Tissue Section - Depression: Brain: Occipital Lobe

T1236062Dep 5 slides
EUR 523

Paraffin Tissue Section - Depression: Brain: Occipital Lobe

T2236062Dep 5 slides
EUR 262

Amyloid-beta Protein (12-28) / Alzheimer's Disease beta-Protein / SP-17 (Human)

018-04 200 μg
EUR 50.76

Genomic DNA - Alzheimer's Disease: Brain: Corpus Callosum, from a single donor

D1236045Alz 50 ug
EUR 562

Genomic DNA - Alzheimer's Disease: Brain: Precentral Gyrus , from a single donor

D1236073Alz 50 ug
EUR 562

Amyloid-beta Protein (1-28) / Alzheimer's Disease beta-Protein / SP-28 (Human)

018-02 200 μg
EUR 108

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 7 different tissues

T6236444Alz 5 slides
EUR 1249

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T6236445Alz 5 slides
EUR 1249

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T6236446Alz 5 slides
EUR 1249

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T6236564Alz 5 slides
EUR 1249

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 8 different tissues

T8236444Alz 5 slides
EUR 713

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T8236445Alz 5 slides
EUR 713

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T8236564Alz 5 slides
EUR 713

cDNA - Monkey (Cynomolgus) Normal Tissue: Brain: Occipital Lobe

C1534062-Cy 40 reactions
EUR 481

Genomic DNA - Alzheimer's Disease: Brain: Medulla oblongata, from a single donor

D1236057Alz 50 ug
EUR 562

Genomic DNA - Alzheimer's Disease: Brain: Postcentral Gyrus , from a single donor

D1236072Alz 50 ug
EUR 562

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T8236446Alz 5 slides
EUR 713

Membrane Protein - Alzheimer's Disease:Brain: Amygdala

P3236036Alz 0.1 mg
EUR 472

Frozen Tissue Section - Human Adult Normal: Brain: Occipital Lobe

T1234062 5 slides
EUR 377

Membrane Protein - Alzheimer's Disease:Brain: Hippocampus

P3236052Alz 0.1 mg
EUR 584

Paraffin Tissue Section - Human Adult Normal: Brain: Occipital Lobe

T2234062 5 slides
EUR 204

Membrane Protein - Human Adult Normal Tissue: Brain: Occipital Lobe

P3234062 0.1 mg
EUR 311

Genomic DNA - Dementia: Brain: Occipital Lobe, from a single donor

D1236062Dem 50 ug
EUR 562

Genomic DNA - Depression: Brain: Occipital Lobe, from a single donor

D1236062Dep 50 ug
EUR 562

Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Occipital Lobe

T1236062PSP 5 slides
EUR 523

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Occipital Lobe

T2236062PSP 5 slides
EUR 262

Normal Rhesus Monkey Occipital lobe (5 slides/pack, single section/slide)

S-RsFPT015 1 unit
EUR 95

Normal Rhesus Monkey Occipital lobe (single section per slide) (5 slides/pack)

RsFPT015 5 slides
EUR 150

Genomic DNA - Human Adult Normal Tissue: Brain, occipital lobe, from a single donor

D1234062 100 ug
EUR 329

Genomic DNA - Progressive Supranuclear Palsy: Brain: Occipital Lobe, from a single donor

D1236062PSP 50 ug
EUR 662

Paraffin Tissue Section - Alzheimers Disease: Brain

T2236035Alz 5 slides
EUR 262

Alzheimers Disease gamma-Secretase Detection Set

PSI-1820 1 Set
EUR 752.1
Description: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by three enzymes (TACE, BACE/BACE2 and γ-secretase) at three distinct sites (α, β and γ respectively). The γ-secretase complex is a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer and is composed of the proteins APH1, nicastrin, PEN2 and presenilin1. Its cleavage of APP results in either the non-toxic p3 (from the α and γ cleavage site) or the toxic Aβ (from the β and γ cleavage site). APH1 was initially identified as a component of the Notch pathway and exists in at least three distinct isoforms with APH1a as the principal isoform present in the γ-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Besides acting as a critical component of the γ-secretase complex, nicastrin is also thought to be involved in cell proliferation and signaling, especially in regards to activation of Notch receptors as loss of nicastrin expression results in mouse embryonic lethality. Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer’s disease.;;For images please see PDF data sheet

Alzheimers Disease B-Amyloid Protein Detection Set

PSI-1812 1 Set
EUR 752.1
Description: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The βamyloid protein precursor (APP) is cleaved by one of two βsecretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for βsecretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer’s disease patients’ brains. BACE was identified by several groups independently and designated β-site APP cleaving enzyme (BACE) . BACE is a transmembrane aspartic protease and co-localizes with APP. BACE2 also cleaves APP at β-site and at a different site within Aβ. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.;;For images please see PDF data sheet

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons

T2236071Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Amygdala

T2236036Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus

T2236079Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus

T2236052Alz 5 slides
EUR 834

Paraffin Tissue Section - Alzheimers Disease: Brain: Corpus Callosum

T2236045Alz 5 slides
EUR 262

PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1

SC119867 10 µg Ask for price

PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2

SC324404 10 µg Ask for price

PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2

SC109639 10 µg Ask for price

Total Protein - Parkinson's Disease: Brain: Frontal Lobe

P1236051Par 1 mg
EUR 542

PSEN2 (GFP-tagged) - Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2

RG202921 10 µg Ask for price

PSEN2 (GFP-tagged) - Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1

RG223613 10 µg Ask for price

Total Protein - Parkinson's Disease: Brain: Parietal Lobe

P1236066Par 1 mg
EUR 542

Total Protein - Parkinson's Disease: Brain: Temporal Lobe

P1236078Par 1 mg
EUR 542

PSEN2 (Myc-DDK-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1

RC223613 10 µg Ask for price

PSEN2 (Myc-DDK-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2

RC202921 10 µg Ask for price

Paraffin Tissue Section - Alzheimers Disease: Brain: Precentral Gyrus (Movement)

T2236073Alz 5 slides
EUR 262

Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, mGFP tagged

RC202921L2 10 µg Ask for price

Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, mGFP tagged

RC202921L4 10 µg Ask for price

Paraffin Tissue Section - Alzheimers Disease: Brain: Postcentral Gyrus (Sensation)

T2236072Alz 5 slides
EUR 262

Total Protein - Multiple Sclerosis Disease: Brain: Frontal Lobe

P1236051Msc 1 mg
EUR 542

Lenti-ORF clone of PSEN2 (mGFP-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1

RC223613L4 10 µg Ask for price

3`UTR clone of presenilin 2 (Alzheimer disease 4) (PSEN2) transcript variant 1 for miRNA target validation

SC207101 10 µg Ask for price

3`UTR clone of presenilin 2 (Alzheimer disease 4) (PSEN2) transcript variant 2 for miRNA target validation

SC207102 10 µg Ask for price

Significantly, the researchers NTF receive 50%, 42%, and 70% of the total grants awarded in Population Studies, Dementia Care, and Brain Aging, respectively, indicating that the NTF researchers fill research gaps. While these results suggest that increased funding associated with the recruitment of new talent, the opportunities for further growth remain, particularly with regard to treatment, care, and health inequalities.