Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by loss of neurons and synaptic transmission interruption, eventually causing cognitive deficits. At the beginning of the disease, the olfactory pathways appear to be most sensitive to tauopathy, while most studies have focused on the plasticity of hippocampal circuits.

Functional network connectivity (FC) and long-term potentiation (LTP), regarded as the substrate plasticity of learning and memory, which is longitudinally assessed on a rat model of P301S of tauopathy follow courses (time and location) pathology of progressive neurodegenerative (ie, at 3, 6, and 9 months of age) and their wild-type (WT) littermates. Using in vivo potency local field (LFP) recordings, beginning (at three months) absorbers in activity oscillates gamma and interference in the coupling phase-amplitude theta-gamma (PAC) found in the olfactory bulb (OB) circuitry P301S mice, which was maintained through the entire program of development of pathology. In contrast, activity LFP oscillations and normal PAC index in the entorhinal cortex, hippocampal CA1 and CA3 core.

Field excitatory postsynaptic potential (fEPSP) recording of collateral Shaffer (SC) -CA1 hippocampal LTP strata of the pyramid reveals significantly altered synaptic responses against high frequency stimulation (HFS): at three months of age, there was no significant difference between the genotype was found in the basal synaptic activity , while signs of short-term plasticity deficits revealed by changes in fEPSPs. At the age of six months, a little deviation found in the basal synaptic activity and significant differences were observed in response to the LTP. The change in network oscillations in the level of OB and disruption in the functioning of the SC-CA1 synapses pyramid strongly suggest that the development of tau pathology causing brain areas, disruption of activity-dependent synaptic transmission functional.

These findings indicate a major change early activity of neurons in the OB circuit before hippocampal synaptic plasticity disorders, may involve tauopathy in anomaly FC. Further studies should determine whether they are deficits in the early oscillation OB and FC network is a mechanism that may potentially promote the emergence of hippocampal synaptic disruption during development tauopathy.

 Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer's Disease
Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease

Use of Biomarkers in ongoing Alzheimer’s Disease Research Protocols

This study aims to describe and discuss the state of the art the use of biomarkers in the ongoing study of disease (AD) Alzheimer’s. A review of 222 ongoing phase 1, 2, 3, and 4 protocols listed in the database clinicaltrials.gov do. All trials (i) subjects enrolled in a clinical disorder and / or diagnosis of preclinical included in the continuum of AD; and (ii) to test the efficacy and / or safety / tolerability of the therapeutic intervention, were analyzed.

The use of biomarkers of amyloid deposition, tau pathology and neurodegeneration among the eligibility criteria and / or the results of the study assessed. Overall, 58.2% of the intervention study was underway on adopting AD biomarker candidates. They largely adopted by studies in the early stages of the drug development process to explore the safety profile of new therapies, and to provide evidence of target engagement and disease-modifying properties.

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS657034-1mg 1mg
EUR 920

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Hippocampus

MBS657034-5x1mg 5x1mg
EUR 3920

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)

MBS640027-5Sections 5Sections
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)

MBS640027-5x5Sections 5x5Sections
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)

MBS640635-5Sections 5Sections
EUR 985

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)

MBS640635-5x5Sections 5x5Sections
EUR 4280

Hippocampus (Alzheimer's Disease) Lysate

XBL-10286 0.1 mg
EUR 922.2
Description: Human hippocamps tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human hippocamps tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the hippocamps tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The hippocamps tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Hippocampus, BioGenomics

MBS652008-40Tests 40Tests
EUR 1195

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Hippocampus, BioGenomics

MBS652008-5x40Tests 5x40Tests
EUR 5155

Hippocampus (Alzheimer's Disease) Cytoplasmic Lysate

XBL-10283 0.1 mg
EUR 273.3
Description: Human brain hippocamps tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Membrane-Protein---Alzheimer's-Disease:Brain:-Hippocampus

P3236052Alz 0.1 mg
EUR 437.15

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS639891-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS639891-5x01mg 5x0.1mg
EUR 2915

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS639875-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS639875-5x01mg 5x0.1mg
EUR 2915

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe

MBS640953-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe

MBS640953-5x5Slides 5x5Slides
EUR 6190

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe

MBS639688-5Slides 5Slides
EUR 880

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe

MBS639688-5x5Slides 5x5Slides
EUR 3820

Tissue, Membrane Protein, Human Adult Normal, Brain, Hippocampus

MBS639797-01mg 0.1mg
EUR 920

Tissue, Membrane Protein, Human Adult Normal, Brain, Hippocampus

MBS639797-5x01mg 5x0.1mg
EUR 3930

Amygdala (Alzheimer's Disease) Membrane Lysate

XBL-10272 0.1 mg
EUR 752.1
Description: Human brain amygdala tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human amygdala tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain amygdala tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain amygdala tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Parkinson's Disease: Brain: Hippocampus

C1236052Par 40 reactions
EUR 730.1

Temporal Lobe (Alzheimer's Disease) Membrane Lysate

XBL-10312 0.1 mg
EUR 752.1
Description: Human brain temporal lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human temporal lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain temporal lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain temporal lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

cDNA - Multiple Sclerosis Disease: Brain: Hippocampus

C1236052Msc 40 reactions
EUR 730.1

Membrane-Protein---Human-Adult-Normal-Tissue:-Brain:-Hippocampus

P3234052 0.1 mg
EUR 569.1

Hippocampus Membrane Lysate

XBL-10180 0.1 mg
EUR 1023
Description: Human brain hippocamps tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human hippocamps tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain hippocamps tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain hippocamps tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain

MBS657525-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain

MBS657525-5x1mg 5x1mg
EUR 3470

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 600.6

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Frozen)

MBS640145-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Frozen)

MBS640145-5x5Slides 5x5Slides
EUR 5155

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Pons

MBS657002-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Pons

MBS657002-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Depression, Brain, Hippocampus (Frozen)

MBS639963-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Depression, Brain, Hippocampus (Frozen)

MBS639963-5x5Slides 5x5Slides
EUR 5155

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Paraffin)

MBS640722-5Slides 5Slides
EUR 985

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Paraffin)

MBS640722-5x5Slides 5x5Slides
EUR 4280

Tissue, Section, Human Disease, Depression, Brain, Hippocampus (Paraffin)

MBS640464-5Slides 5Slides
EUR 985

Tissue, Section, Human Disease, Depression, Brain, Hippocampus (Paraffin)

MBS640464-5x5Slides 5x5Slides
EUR 4280

Tissue Section, Human Disease, Parkinson, Brain, Hippocampus (Paraffin)

MBS640134-5Slides 5Slides
EUR 985

Tissue Section, Human Disease, Parkinson, Brain, Hippocampus (Paraffin)

MBS640134-5x5Slides 5x5Slides
EUR 4280

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Thalamus

MBS657447-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Thalamus

MBS657447-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS657576-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala

MBS657576-5x1mg 5x1mg
EUR 3470

Tissue, Genomic DNA, Human Disease, Alzheimer's Disease, Alzheimer's Brain, BioGenomics

MBS654298-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease, Alzheimer's Disease, Alzheimer's Brain, BioGenomics

MBS654298-5x005mg 5x0.05mg
EUR 3075

cDNA - Alzheimer's Disease: Brain: Pons

C1236071Alz 40 reactions
EUR 600.6

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Cerebellum

MBS657508-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Cerebellum

MBS657508-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS657032-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe

MBS657032-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe

MBS657046-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe

MBS657046-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe

MBS657343-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe

MBS657343-5x1mg 5x1mg
EUR 3470

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Thalamus

C1236079Alz 40 reactions
EUR 600.6

Tissue cDNA, First Strand, Human Diseased (Adult), Parkinson's Disease, Brain, Hippocampus, BioGenomics

MBS652003-40Tests 40Tests
EUR 1195

Tissue cDNA, First Strand, Human Diseased (Adult), Parkinson's Disease, Brain, Hippocampus, BioGenomics

MBS652003-5x40Tests 5x40Tests
EUR 5155

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum

MBS657061-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum

MBS657061-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe

MBS657066-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe

MBS657066-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Hippocampus (Frozen)

MBS640864-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Hippocampus (Frozen)

MBS640864-5x5Slides 5x5Slides
EUR 5155

cDNA - Alzheimer's Disease: Brain: Cerebellum

C1236039Alz 40 reactions
EUR 600.6

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus

MBS657142-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus

MBS657142-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus

MBS657585-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus

MBS657585-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Hippocampus (Paraffin)

MBS640289-5Slides 5Slides
EUR 985

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Hippocampus (Paraffin)

MBS640289-5x5Slides 5x5Slides
EUR 4280

cDNA - Alzheimer's Disease: Brain: Frontal Lobe

C1236051Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Parietal Lobe

C1236066Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Temporal Lobe

C1236078Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Occipital Lobe

C1236062Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Precentral Gyrus

C1236073Alz 40 reactions
EUR 600.6

cDNA - Alzheimer's Disease: Brain: Postcentral Gyrus

C1236072Alz 40 reactions
EUR 600.6

OCPB00493-100UG - Hippocampus Membrane Lysate

OCPB00493-100UG 0.1mg
EUR 979

Total-Protein---Alzheimer's-Disease:-Brain:-Hippocampus

P1236052Alz 1 mg
EUR 499.45

Tissue cDNA, First Strand, Human Diseased (Adult), Dementia, Brain, Hippocampus, BioGenomics

MBS652042-40Tests 40Tests
EUR 1195

Tissue cDNA, First Strand, Human Diseased (Adult), Dementia, Brain, Hippocampus, BioGenomics

MBS652042-5x40Tests 5x40Tests
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)

MBS640021-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)

MBS640021-5x5Slides 5x5Slides
EUR 3170

Tissue cDNA, First Strand, Human Diseased (Adult), Depression, Brain, Hippocampus, BioGenomics

MBS652208-40Tests 40Tests
EUR 1195

Tissue cDNA, First Strand, Human Diseased (Adult), Depression, Brain, Hippocampus, BioGenomics

MBS652208-5x40Tests 5x40Tests
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)

MBS640539-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)

MBS640539-5x5Sections 5x5Sections
EUR 2145

Tissue cDNA, First Strand, Human Diseased (Adult), Multiple Sclerosis, Brain, Hippocampus, BioGenomics

MBS652553-40Tests 40Tests
EUR 1195

Tissue cDNA, First Strand, Human Diseased (Adult), Multiple Sclerosis, Brain, Hippocampus, BioGenomics

MBS652553-5x40Tests 5x40Tests
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)

MBS640843-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)

MBS640843-5x5Sections 5x5Sections
EUR 3170

Genomic DNA - Alzheimer's Disease: Brain, from a single donor

D1236035Alz 50 ug
EUR 420.7

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)

MBS640521-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)

MBS640521-5x5Sections 5x5Sections
EUR 2145

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Brain, BioGenomics

MBS638606-005mg 0.05mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Brain, BioGenomics

MBS638606-5x005mg 5x0.05mg
EUR 2735

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)

MBS640320-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)

MBS640320-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)

MBS640174-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)

MBS640174-5x5Sections 5x5Sections
EUR 3170

Genomic DNA - Alzheimer's Disease: Brain: Pons, from a single donor

D1236071Alz 50 ug
EUR 420.7

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)

MBS640834-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)

MBS640834-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)

MBS640882-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)

MBS640882-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)

MBS640323-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)

MBS640323-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)

MBS640297-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)

MBS640297-5x5Sections 5x5Sections
EUR 3170

Dog Brain, Hippocampus Total Protein

DT-203 0.5mg
EUR 176

Cat Brain, Hippocampus Total Protein

FT-203 0.5mg
EUR 176

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)

MBS640497-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)

MBS640497-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)

MBS640325-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)

MBS640325-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)

MBS640199-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)

MBS640199-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)

MBS640253-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)

MBS640253-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)

MBS640659-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)

MBS640659-5x5Sections 5x5Sections
EUR 2145

Genomic DNA - Alzheimer's Disease: Brain: Thalamus, from a single donor

D1236079Alz 50 ug
EUR 420.7

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)

MBS640808-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)

MBS640808-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)

MBS640156-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)

MBS640156-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)

MBS640226-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)

MBS640226-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)

MBS639971-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)

MBS639971-5x5Slides 5x5Slides
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)

MBS640705-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)

MBS640705-5x5Sections 5x5Sections
EUR 2145

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, BioGenomics

MBS652514-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, BioGenomics

MBS652514-5x40Tests 5x40Tests
EUR 4250

Bovine Brain, Hippocampus Total Protein

BT-203 0.5mg
EUR 153

Genomic DNA - Alzheimer's Disease: Brain: Cerebellum, from a single donor

D1236039Alz 50 ug
EUR 420.7

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)

MBS640817-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)

MBS640817-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)

MBS640034-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)

MBS640034-5x5Sections 5x5Sections
EUR 2145

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Pons, BioGenomics

MBS654522-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Pons, BioGenomics

MBS654522-5x005mg 5x0.05mg
EUR 3075

Genomic DNA - Alzheimer's Disease: Brain: Frontal Lobe, from a single donor

D1236051Alz 50 ug
EUR 420.7

Frozen-Tissue-Section---Alzheimer's-Disease:-Brain:-Hippocampus

T1236052Alz 5 slides
EUR 727.3

Genomic DNA - Alzheimer's Disease: Brain: Parietal Lobe, from a single donor

D1236066Alz 50 ug
EUR 420.7

Genomic DNA - Alzheimer's Disease: Brain: Temporal Lobe, from a single donor

D1236078Alz 50 ug
EUR 420.7

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)

MBS640442-5Slides 5Slides
EUR 725

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)

MBS640442-5x5Slides 5x5Slides
EUR 3100

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Pons, BioGenomics

MBS652281-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Pons, BioGenomics

MBS652281-5x40Tests 5x40Tests
EUR 4250

Genomic DNA - Alzheimer's Disease: Brain: Occipital Lobe, from a single donor

D1236062Alz 50 ug
EUR 420.7

Genomic DNA - Alzheimer's Disease: Brain: Corpus Callosum, from a single donor

D1236045Alz 50 ug
EUR 420.7

Genomic DNA - Alzheimer's Disease: Brain: Precentral Gyrus , from a single donor

D1236073Alz 50 ug
EUR 420.7

Selection of participants supported biologically based largely on biomarkers of amyloid deposition, while the use of a biomarker as a result of the study largely depends on markers of neurodegeneration. Biomarkers play an important role in the design and conduction of research protocols targeting AD. However, their clinical validity, utility, and cost-effectiveness in the “real world” remains to be clarified.