Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease
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Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized by loss of neurons and synaptic transmission interruption, eventually causing cognitive deficits. At the beginning of the disease, the olfactory pathways appear to be most sensitive to tauopathy, while most studies have focused on the plasticity of hippocampal circuits.
Functional network connectivity (FC) and long-term potentiation (LTP), regarded as the substrate plasticity of learning and memory, which is longitudinally assessed on a rat model of P301S of tauopathy follow courses (time and location) pathology of progressive neurodegenerative (ie, at 3, 6, and 9 months of age) and their wild-type (WT) littermates. Using in vivo potency local field (LFP) recordings, beginning (at three months) absorbers in activity oscillates gamma and interference in the coupling phase-amplitude theta-gamma (PAC) found in the olfactory bulb (OB) circuitry P301S mice, which was maintained through the entire program of development of pathology. In contrast, activity LFP oscillations and normal PAC index in the entorhinal cortex, hippocampal CA1 and CA3 core.
Field excitatory postsynaptic potential (fEPSP) recording of collateral Shaffer (SC) -CA1 hippocampal LTP strata of the pyramid reveals significantly altered synaptic responses against high frequency stimulation (HFS): at three months of age, there was no significant difference between the genotype was found in the basal synaptic activity , while signs of short-term plasticity deficits revealed by changes in fEPSPs. At the age of six months, a little deviation found in the basal synaptic activity and significant differences were observed in response to the LTP. The change in network oscillations in the level of OB and disruption in the functioning of the SC-CA1 synapses pyramid strongly suggest that the development of tau pathology causing brain areas, disruption of activity-dependent synaptic transmission functional.
These findings indicate a major change early activity of neurons in the OB circuit before hippocampal synaptic plasticity disorders, may involve tauopathy in anomaly FC. Further studies should determine whether they are deficits in the early oscillation OB and FC network is a mechanism that may potentially promote the emergence of hippocampal synaptic disruption during development tauopathy.
Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease
Use of Biomarkers in ongoing Alzheimer’s Disease Research Protocols
This study aims to describe and discuss the state of the art the use of biomarkers in the ongoing study of disease (AD) Alzheimer’s. A review of 222 ongoing phase 1, 2, 3, and 4 protocols listed in the database clinicaltrials.gov do. All trials (i) subjects enrolled in a clinical disorder and / or diagnosis of preclinical included in the continuum of AD; and (ii) to test the efficacy and / or safety / tolerability of the therapeutic intervention, were analyzed.
The use of biomarkers of amyloid deposition, tau pathology and neurodegeneration among the eligibility criteria and / or the results of the study assessed. Overall, 58.2% of the intervention study was underway on adopting AD biomarker candidates. They largely adopted by studies in the early stages of the drug development process to explore the safety profile of new therapies, and to provide evidence of target engagement and disease-modifying properties.
Membrane Protein from Alzheimer's Disease:Brain: Temporal Lobe
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Hippocampus
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Hippocampus Abundant Transcript-Like Protein 2 (HIATL2) Antibody
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Cerebellum
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Pons
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Thalamus
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Corpus Callosum
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Frontal Lobe
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Medulla oblongata
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Occipital Lobe
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Parietal Lobe
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Postcentral Gyrus
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Precentral Gyrus
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Total Protein from Alzheimer's Disease: Brain: Temporal Lobe
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
cDNA from Multiple Sclerosis Disease: Brain: Hippocampus
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
cDNA from Human Adult Normal Tissue: Brain: Hippocampus
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Hippocampus
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Frozen Tissue Section - Human Adult Normal: Brain: Hippocampus
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Paraffin Tissue Section - Human Adult Normal: Brain: Hippocampus
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Alzheimer's Disease: Brain: Occipital Lobe
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Alzheimer's Disease: Brain: Parietal Lobe
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Alzheimer's Disease: Brain: Postcentral Gyrus
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Alzheimer's Disease: Brain: Precentral Gyrus
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
cDNA from Alzheimer's Disease: Brain: Temporal Lobe
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Alzheimer's Disease: Corpus Callosum
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Alzheimer's Disease: Occipital Lobe
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Alzheimer's Disease: Postcentral Gyrus
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Total RNA from Alzheimer's Disease: Precentral Gyrus
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Total RNA from Human Adult Normal Tissue: Brain: Hippocampus
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.
Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
A very simple, inexpensive and effective tool for Tuberculosis/ Mycobacterium research. Spoligotyping is a PCR-based Method to Simultaneously Detect and Type Mycobacterium Tuberculosis Complex Bacteria. Spoligotyping, which uses RLB (Reversed Line Blotting) offers an alternative for typical Southern blotting when rapid results are required. The method is particularly useful to simultaneously detect and type M. tuberculosis complex bacteria in clinical samples (suspected nosocomial infections, outbreaks in prisons, etc.). The level of differentiation by spoligotyping is less compared to IS6110 fingerprinting for strains having five or more IS6110 copies, but higher for strains with less than five copies. Thus, Spoligotyping is a preferred method to type M. bovis strains, which usually contain only one or two IS6110 copies. Note, that Mycobacterium bovis can be recognized by the absence of reactivity with spacers 39-43.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Genomic DNA from Alzheimer's Disease: Brain: Thalamus, from a single donor
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Genomic DNA from Alzheimer's Disease: Brain: Cerebellum, from a single donor
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.
Human Membrane Protein, Palmitoylated 5 (MPP5) Protein
Selection of participants supported biologically based largely on biomarkers of amyloid deposition, while the use of a biomarker as a result of the study largely depends on markers of neurodegeneration. Biomarkers play an important role in the design and conduction of research protocols targeting AD. However, their clinical validity, utility, and cost-effectiveness in the “real world” remains to be clarified.
Membrane Protein from Alzheimer's Disease:Brain: Temporal Lobe 
Total Protein from Alzheimer's Disease: Brain: Hippocampus 
cDNA from Alzheimer's Disease: Brain: Hippocampus 
Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus 
Hippocampus 
Membrane Protein from Human Adult Normal Tissue: Brain: Hippocampus 
Human Hippocampus Tissue Lysate 
cDNA from Dementia: Brain: Hippocampus 
cDNA from Depression: Brain: Hippocampus 
Combined Hippocampus, Cortex, and Ventricular 
Total Protein from Alzheimer's Disease: Brain  Antibody)
Hippocampus Abundant Transcript-Like Protein 2 (HIATL2) Antibody 
Total Protein from Alzheimer's Disease: Brain: Amygdala 
Total Protein from Alzheimer's Disease: Brain: Cerebellum 
Total Protein from Alzheimer's Disease: Brain: Pons 
Total Protein from Alzheimer's Disease: Brain: Thalamus 
cDNA from Parkinson's Disease: Brain: Hippocampus 
Frozen Tissue Section - Dementia: Brain: Hippocampus 
Frozen Tissue Section - Depression: Brain: Hippocampus 
Paraffin Tissue Section - Dementia: Brain: Hippocampus 
Paraffin Tissue Section - Depression: Brain: Hippocampus 
cDNA from Alzheimer's Disease: Brain 
Human Alzheimer's Disease Primer Library 
Mouse Hippocampus abundant transcript 1 protein, Hiat1 ELISA KIT 
Rat Hippocampus abundant transcript- like protein 1, Hiatl1 ELIS 
Human Hippocampus abundant transcript- like protein 1, HIATL1 EL 
Mouse Hippocampus abundant transcript- like protein 1, Hiatl1 EL 
Human Hippocampus abundant transcript 1 protein, HIAT1 ELISA KIT 
Bovine Hippocampus abundant transcript- like protein 1, HIATL1 E 
Total Protein from Human Adult Normal Tissue: Brain: Hippocampus 
Total Protein from Alzheimer's Disease: Brain: Corpus Callosum 
Total Protein from Alzheimer's Disease: Brain: Frontal Lobe 
Total Protein from Alzheimer's Disease: Brain: Medulla oblongata 
Total Protein from Alzheimer's Disease: Brain: Occipital Lobe 
Total Protein from Alzheimer's Disease: Brain: Parietal Lobe 
Total Protein from Alzheimer's Disease: Brain: Postcentral Gyrus 
Total Protein from Alzheimer's Disease: Brain: Precentral Gyrus 
Total Protein from Alzheimer's Disease: Brain: Temporal Lobe 
cDNA from Multiple Sclerosis Disease: Brain: Hippocampus 
Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus 
Paraffin Tissue Section - Parkinson's Disease: Brain: Hippocampus 
cDNA from Alzheimer's Disease: Brain: Amygdala 
cDNA from Alzheimer's Disease: Brain: Cerebellum 
cDNA from Alzheimer's Disease: Brain: Pons 
cDNA from Alzheimer's Disease: Brain: Thalamus 
Total RNA from Alzheimer's Disease: Brain 
Total RNA from Alzheimer's Disease: Pons 
Frozen Tissue Section - Alzheimer's Disease: Brain 
cDNA from Human Adult Normal Tissue: Brain: Hippocampus  Normal Tissue: Brain: Hippocampus)
cDNA from Monkey (Cynomolgus) Normal Tissue: Brain: Hippocampus 
Frozen Tissue Section - Human Adult Normal: Brain: Hippocampus 
Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus 
Paraffin Tissue Section - Human Adult Normal: Brain: Hippocampus 
Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus 
Non-Ab Component of Alzheimer's Disease Amyloid 
cDNA from Alzheimer's Disease: Brain: Frontal Lobe 
cDNA from Alzheimer's Disease: Brain: Occipital Lobe 
cDNA from Alzheimer's Disease: Brain: Parietal Lobe 
cDNA from Alzheimer's Disease: Brain: Postcentral Gyrus 
cDNA from Alzheimer's Disease: Brain: Precentral Gyrus 
cDNA from Alzheimer's Disease: Brain: Temporal Lobe 
Total RNA from Alzheimer's Disease: Corpus Callosum 
Total RNA from Alzheimer's Disease: Frontal Lobe 
Total RNA from Alzheimer's Disease: Occipital Lobe 
Total RNA from Alzheimer's Disease: Parietal Lobe 
Total RNA from Alzheimer's Disease: Postcentral Gyrus 
Total RNA from Alzheimer's Disease: Precentral Gyrus 
Total RNA from Alzheimer's Disease: Temporal Lobe 
Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala 
Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum 
Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary 
Frozen Tissue Section - Alzheimer's Disease: Brain: Pons 
Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus 
Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum 
Total RNA from Human Adult Normal Tissue: Brain: Hippocampus 
Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum 
Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe 
Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata 
Frozen Tissue Section - Alzheimer's Disease: Brain: Occipital Lobe 
Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe 
Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus 
Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus 
Frozen Tissue Section - Alzheimer's Disease: Brain: Temporal Lobe 
Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata 
Membrane Protein Extraction Kit  Protein)
Membrane Cofactor Protein (CD46) Protein 
Golgi Membrane Protein 1 Protein 
Dialysis Membrane 
Spoligotyping Membrane 
Membrane Remover 
Genomic DNA from Alzheimer's Disease: Brain, from a single donor )
EMP-1 (Epithelial Membrane Protein) )
Mouse Membrane cofactor protein (Cd46) 
Mammalian Membrane Protein Extraction Kit  Antibody)
Membrane Cofactor Protein (MCP) Antibody 
Outer membrane protein A Antibody  Antibody)
Membrane Protein MLC1 (MLC1) Antibody  Antibody)
Membrane Cofactor Protein (CD46) Antibody  Protein)
Glomerular Basement Membrane (GBM) Protein 
Campylobacter jejuni outer membrane Protein 
Entamoeba dispar outer membrane Protein 
Helicobacter Pylori Outer Membrane Protein 
Prostate Specific Membrane Antigen Protein  Antibody)
Membrane Protein FAM174A (FAM174A) Antibody 
Membrane Protein from Lupus: Kidney 
Prolytic Membrane Protein Extraction Kit )
Recombinant Membrane Cofactor Protein (MCP) 
Human Golgi membrane protein GP73 Protein  Protein)
Human Membrane Cofactor Protein (MCP) Protein  Protein)
Rat Membrane Cofactor Protein (MCP) Protein  Protein)
Mouse Membrane Cofactor Protein (MCP) Protein 
Vesicle-Associated Membrane Protein 7 Protein  Protein)
CXADR-Like Membrane Protein (CLMP) Protein 
Bacterial Outer Membrane Protein-A Protein 
Probable outer membrane protein pmp10 Protein 
Lysosomal-Associated Membrane Protein 2 Protein 
Vesicle-Associated Membrane Protein 4 Protein 
Genomic DNA from Alzheimer's Disease: Brain: Pons, from a single donor 
Genomic DNA from Alzheimer's Disease: Brain: Thalamus, from a single donor 
Genomic DNA from Alzheimer's Disease: Brain: Cerebellum, from a single donor  Protein)
Human Membrane Protein, Palmitoylated 5 (MPP5) Protein  Protein)
Human Membrane Protein, Palmitoylated 6 (MPP6) Protein  Protein)
Mouse Membrane Protein, Palmitoylated 2 (MPP2) Protein  Protein)
Human Membrane Protein, Palmitoylated 2 (MPP2) Protein  Protein)
Mouse Membrane Protein, Palmitoylated 6 (MPP6) Protein  Protein)
Campylobacter coli outer membrane protein (OMP) Protein  Protein)
Salmonella Typhi Outer Membrane Protein (omp) Protein 
Salmonella Enteritidis Outer Membrane Protein-A Protein