Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.

To diagnose and treat early stages (preclinical) Alzheimer’s disease (AD) patients, we need the body-fluid-based biomarkers that reflect the processes that occur at this stage, but the current knowledge on the processes associated less. As human studies on the (possible) onset and early stage AD would be very expensive and time consuming, we investigated the potential value of animal models of AD to help fill this knowledge gap.

We provide a comprehensive overview of the processes associated with AD pathogenesis and biomarkers, the current knowledge on biomarker-associated AD comes from the brains of humans and animals and body fluids, comparison of biomarkers obtained in AD human and frequently used animal model of AD, and appeared body-fluid-based biomarkers. In human studies, amyloid beta (Aβ), hyperphosphorylated tau (P-tau), the amount of tau (T-tau), neurogranin, SNAP-25, glial fibrillary acidic protein (GFAP), YKL-40, and especially light Neurofilament (NFL ) is often measured. In animal studies, the emphasis was largely on Aβ.

Although a direct comparison between human AD (familial and sporadic) and (largely genetic) animal models of AD can not be made, still, in the brain, cerebrospinal fluid (CSF), and blood, the majority of similar trends were observed for stage AD humans and AD animal stage Model life. This shows the potential value of animal models in understanding the early stages of AD and the beginning of AD. In addition, animal studies can be intelligently designed to provide mechanistic information about the interrelationships between the different processes longitudinally AD and may also include a combination of the different conditions which may reflect comorbidity in human AD, according to Research Mastermind approach.


It may not be surprising that the brain as an organ rich in lipids show impaired lipid profile in neurodegenerative conditions such as Alzheimer’s disease. It is, however, more challenging to detect these changes because they may only occur in a small spatial area. Editorial highlights work by Rich et al. using a technology called MALDI IMS raising to identify the up or downregulation of specific lipids in and around the amyloid plaques, one of the pathological hallmarks of Alzheimer’s disease.

Interestingly, lipid changes as it parallel to the structure of myelin interrupted just at the border between white matter and gray.

 Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.
Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.

Multifunction Glycogen Synthase Kinase Ligands with Inhibitory Activity 3 as a New Direction in Alzheimer’s Disease Drug Research.

Alzheimer’s disease (AD) belong to the most common form of dementia that causes progressive loss of brain cells and leads to memory impairment and decreased ability to think more. There has been no effective treatment for AD; Therefore, the search for new drugs that can improve memory and other cognitive functions is one of the hot research topic worldwide. Scientific efforts are also directed combat the behavioral and psychological symptoms of dementia, which is an integral part of the disease.

Several studies have shown that glycogen synthase kinase 3 beta (GSK3β) plays an important role in the pathogenesis of AD. In addition, inhibition of GSK3β provided beneficial effects on memory enhancement in several animal models of AD. This review aims to update the most recent report on the discovery of novel multifunctional ligands with GSK3β inhibitory activity as potential drugs for the treatment of symptoms and disease-modifying AD.

Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus

T2236052Alz 5 slides
EUR 758

Paraffin Tissue Section - Alzheimers Disease: Brain: Frontal Lobe

T2236051Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Parietal Lobe

T2236066Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Temporal Lobe

T2236078Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Corpus Callosum

T2236045Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Occipital Lobe

T2236062Alz 5 slides
EUR 238

Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala

T1236036Alz 5 slides
EUR 475

Paraffin Tissue Section - Alzheimers Disease: Brain: Precentral Gyrus (Movement)

T2236073Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Postcentral Gyrus (Sensation)

T2236072Alz 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Amygdala

T2236036Par 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Amygdala

T2236036Msc 5 slides
EUR 238

Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T2236039Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T2236057Alz 5 slides
EUR 475

Paraffin Tissue Section - Human Adult Normal: Brain: Amygdala

T2234036 5 slides
EUR 330

Frozen Tissue Section - Parkinson's Disease: Brain: Amygdala

T1236036Par 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 729

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 8 different tissues

T8236444Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T8236445Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T8236564Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T8236446Alz 5 slides
EUR 648

Frozen Tissue Section - Alzheimer's Disease: Brain

T1236035Alz 5 slides
EUR 475

Total Protein - Alzheimer's Disease: Brain: Amygdala

P1236036Alz 1 mg
EUR 471

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons

T1236071Alz 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Amygdala

T1236036Msc 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus

T1236079Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe

T1236066Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary

T1236068Alz 5 slides
EUR 883

Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T1236039Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus

T1236052Alz 5 slides
EUR 883

Paraffin Tissue Section - Parkinson's Disease: Brain

T2236035Par 5 slides
EUR 238

Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe

T1236051Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Temporal Lobe

T1236078Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Occipital Lobe

T1236062Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum

T1236045Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus

T1236073Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T1236057Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus

T1236072Alz 5 slides
EUR 475

Paraffin Tissue Section - Parkinson's Disease: Brain: Pons

T2236071Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Thalamus

T2236079Par 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain

T2236035Msc 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Cerebellum

T2236039Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Hippocampus

T2236052Par 5 slides
EUR 758

Paraffin Tissue Section - Parkinson's Disease: Brain: Frontal Lobe

T2236051Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Parietal Lobe

T2236066Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Temporal Lobe

T2236078Par 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Pons

T2236071Msc 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T2236062Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Corpus Callosum

T2236045Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Precentral Gyrus

T2236073Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Medulla oblongata

T2236057Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Postcentral Gyrus

T2236072Par 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Thalamus

T2236079Msc 5 slides
EUR 238

Amygdala (Alzheimer's Disease) Lysate

XBL-10274 0.1 mg
EUR 796.2
Description: Human amygdala tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human amygdala tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the amygdala tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The amygdala tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Cerebellum

T2236039Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus

T2236052Msc 5 slides
EUR 758

Membrane Protein - Alzheimer's Disease:Brain: Amygdala

P3236036Alz 0.1 mg
EUR 410

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Frontal Lobe

T2236051Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Parietal Lobe

T2236066Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe

T2236062Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Temporal Lobe

T2236078Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Corpus Callosum

T2236045Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Precentral Gyrus

T2236073Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Medulla oblongata

T2236057Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Postcentral Gyrus

T2236072Msc 5 slides
EUR 238

Amygdala (Alzheimer's Disease) Membrane Lysate

XBL-10272 0.1 mg
EUR 752.1
Description: Human brain amygdala tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human amygdala tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain amygdala tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain amygdala tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Paraffin Tissue Section - Congenital heart disease: Heart

T2236122Hd-3 5 slides
EUR 238

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 7 different tissues

T6236444Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T6236445Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T6236446Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T6236564Alz 5 slides
EUR 1135

Frozen Tissue Section - Human Adult Normal: Brain: Amygdala

T1234036 5 slides
EUR 343

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung

T2236152Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon

T2236090Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver

T2236149Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Brain Tumor

T2235035 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Stomach

T2236248Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Esophagus

T2236106Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Pancreas

T2236188Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid

T2236189Dia 5 slides
EUR 629

Paraffin Tissue Section - Dementia: Brain: Thalamus

T2236079Dem 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow

T2236024Dia 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Thalamus

T2236079Dep 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Hippocampus

T2236052Dem 5 slides
EUR 758

Paraffin Tissue Section - Human Adult Normal: Brain

T2234035 5 slides
EUR 185

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle

T2236171Dia 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Hippocampus

T2236052Dep 5 slides
EUR 758

Paraffin Tissue Section - Human Brain Tumor: Epndymoma

T2235035-6 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Frontal Lobe

T2236051Dem 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Parietal Lobe

T2236066Dem 5 slides
EUR 238

Paraffin Tissue Section - Human Brain Tumor: Gliocytoma

T2235035-7 5 slides
EUR 238

Paraffin Tissue Section - Human Brain Tumor: Meningioma

T2235035-9 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Temporal Lobe

T2236078Dem 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Frontal Lobe

T2236051Dep 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Occipital Lobe

T2236062Dem 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Parietal Lobe

T2236066Dep 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum

T2236227Dia 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Temporal Lobe

T2236078Dep 5 slides
EUR 238

Total Protein - Parkinson's Disease: Brain: Amygdala

P1236036Par 1 mg
EUR 471

Paraffin Tissue Section - Depression: Brain: Occipital Lobe

T2236062Dep 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Pons

T2234071 5 slides
EUR 185

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

T2236230Dia 5 slides
EUR 238

Frozen Tissue Section - Parkinson's Disease: Brain

T1236035Par 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

T2236101Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Insula

T2234055 5 slides
EUR 185

Paraffin Tissue Section - Human Brain Tumor: Craniopharyngioma

T2235035-4 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Midbrain

T2234059 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Thalamus

T2234079 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Pituitary

T2234068 5 slides
EUR 758

Paraffin Tissue Section - Human Brain Tumor: Ependymal Glioma

T2235035-5 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum

T2234039 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Hippocampus

T2234052 5 slides
EUR 629

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Fibrous)

T2235035-10 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Diencephalon

T2234049 5 slides
EUR 185

Paraffin Tissue Section - Human Brain Tumor: Meningioma (Necrotic)

T2235035-11 5 slides
EUR 238

Frozen Tissue Section - Parkinson's Disease: Brain: Pons

T1236071Par 5 slides
EUR 475

Paraffin Tissue Section - Human Adult Normal: Brain: Optic Nerve

T2234064 5 slides
EUR 330

Paraffin Tissue Section - Human Brain Tumor: Pilocytic Astrocytoma

T2235035-13 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Frontal Lobe

T2234051 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Pineal Gland

T2234067 5 slides
EUR 330

Paraffin Tissue Section - Human Adult Normal: Brain: Parietal Lobe

T2234066 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Basal Ganglia

T2234037 5 slides
EUR 330

Paraffin Tissue Section - Human Adult Normal: Brain: Temporal Lobe

T2234078 5 slides
EUR 185

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade I

T2235035-1 5 slides
EUR 238

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade II

T2235035-2 5 slides
EUR 238

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Pons

T2236071PSP 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Choroid Plexus

T2234044 5 slides
EUR 330

Paraffin Tissue Section - Human Adult Normal: Brain: Occipital Lobe

T2234062 5 slides
EUR 185

Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade III

T2235035-3 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum (left)

T2234040 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebral Cortex

T2234042 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Corpus Callosum

T2234045 5 slides
EUR 185

Frozen Tissue Section - Parkinson's Disease: Brain: Thalamus

T1236079Par 5 slides
EUR 475

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum (right)

T2234041 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Olfactory ( region)

T2234063 5 slides
EUR 330

Paraffin Tissue Section - Human Adult Normal: Brain: Precentral Gyrus

T2234073 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Vermis Cerebelli

T2234082 5 slides
EUR 330

Frozen Tissue Section - Parkinson's Disease: Brain: Pituitary

T1236068Par 5 slides
EUR 883

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebral Meninges

T2234043 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Corpora Mamillare

T2234047 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Medulla Oblongata

T2234057 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Postcentral Gyrus

T2234072 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Tonsilla Cerebelli

T2234080 5 slides
EUR 330

Paraffin Tissue Section Panel - Mouse Whole Brain Segmentation Panel

T8334035 5 slides
EUR 580

Frozen Tissue Section - Parkinson's Disease: Brain: Cerebellum

T1236039Par 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 729

Paraffin Tissue Section - Human Brain Tumor: Malignant Oligodendroglioma

T2235035-8 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellar Peduncles

T2234038 5 slides
EUR 185

Paraffin Tissue Section - Human Adult Normal: Brain: Tuberculum Cinereum

T2234081 5 slides
EUR 330

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Cerebellum

T2236039PSP 5 slides
EUR 238

Total Protein - Multiple Sclerosis Disease: Brain: Amygdala

P1236036Msc 1 mg
EUR 471

Frozen Tissue Section - Parkinson's Disease: Brain: Parietal Lobe

T1236066Par 5 slides
EUR 475

Paraffin Tissue Section - Human Adult Normal: Blood Vessel: Brain Artery

T2234014 5 slides
EUR 185

Frozen Tissue Section - Parkinson's Disease: Brain: Frontal Lobe

T1236051Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Temporal Lobe

T1236078Par 5 slides
EUR 475

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Frontal Lobe

T2236051PSP 5 slides
EUR 238

Frozen Tissue Section - Multiple Sclerosis Disease: Brain

T1236035Msc 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T1236062Par 5 slides
EUR 475

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Brain I, 7 different tissues

T8234444 5 slides
EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Brain II, 7 different tissues

T8234445 5 slides
EUR 242

Paraffin Tissue Section Panel - Human Adult Normal Tissue, Brain IV, 7 different tissues

T8234564 5 slides
EUR 242

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Parietal Lobe

T2236066PSP 5 slides
EUR 238

GSK3β inhibitory activity of compounds with pharmacological approach appears to be effective for treating the causes and symptoms of AD because they reduce neuroinflammation and pathological excellence in animal models of AD and provide relief from cognitive and neuropsychiatric symptoms. These compounds have the potential to be used as a drug for the treatment of AD, but their exact pharmacological, pharmacokinetic, toxicology and clinical profile needs to be defined.