Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.

To diagnose and treat early stages (preclinical) Alzheimer’s disease (AD) patients, we need the body-fluid-based biomarkers that reflect the processes that occur at this stage, but the current knowledge on the processes associated less. As human studies on the (possible) onset and early stage AD would be very expensive and time consuming, we investigated the potential value of animal models of AD to help fill this knowledge gap.

We provide a comprehensive overview of the processes associated with AD pathogenesis and biomarkers, the current knowledge on biomarker-associated AD comes from the brains of humans and animals and body fluids, comparison of biomarkers obtained in AD human and frequently used animal model of AD, and appeared body-fluid-based biomarkers. In human studies, amyloid beta (Aβ), hyperphosphorylated tau (P-tau), the amount of tau (T-tau), neurogranin, SNAP-25, glial fibrillary acidic protein (GFAP), YKL-40, and especially light Neurofilament (NFL ) is often measured. In animal studies, the emphasis was largely on Aβ.

Although a direct comparison between human AD (familial and sporadic) and (largely genetic) animal models of AD can not be made, still, in the brain, cerebrospinal fluid (CSF), and blood, the majority of similar trends were observed for stage AD humans and AD animal stage Model life. This shows the potential value of animal models in understanding the early stages of AD and the beginning of AD. In addition, animal studies can be intelligently designed to provide mechanistic information about the interrelationships between the different processes longitudinally AD and may also include a combination of the different conditions which may reflect comorbidity in human AD, according to Research Mastermind approach.


It may not be surprising that the brain as an organ rich in lipids show impaired lipid profile in neurodegenerative conditions such as Alzheimer’s disease. It is, however, more challenging to detect these changes because they may only occur in a small spatial area. Editorial highlights work by Rich et al. using a technology called MALDI IMS raising to identify the up or downregulation of specific lipids in and around the amyloid plaques, one of the pathological hallmarks of Alzheimer’s disease.

Interestingly, lipid changes as it parallel to the structure of myelin interrupted just at the border between white matter and gray.

Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.
Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals.

Multifunction Glycogen Synthase Kinase Ligands with Inhibitory Activity 3 as a New Direction in Alzheimer’s Disease Drug Research.

Alzheimer’s disease (AD) belong to the most common form of dementia that causes progressive loss of brain cells and leads to memory impairment and decreased ability to think more. There has been no effective treatment for AD; Therefore, the search for new drugs that can improve memory and other cognitive functions is one of the hot research topic worldwide. Scientific efforts are also directed combat the behavioral and psychological symptoms of dementia, which is an integral part of the disease.

Several studies have shown that glycogen synthase kinase 3 beta (GSK3β) plays an important role in the pathogenesis of AD. In addition, inhibition of GSK3β provided beneficial effects on memory enhancement in several animal models of AD. This review aims to update the most recent report on the discovery of novel multifunctional ligands with GSK3β inhibitory activity as potential drugs for the treatment of symptoms and disease-modifying AD.

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons
T2236071Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus
T2236079Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus
T2236052Alz 5 slides
EUR 834

Paraffin Tissue Section - Alzheimers Disease: Brain: Frontal Lobe
T2236051Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Parietal Lobe
T2236066Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Temporal Lobe
T2236078Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Corpus Callosum
T2236045Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Occipital Lobe
T2236062Alz 5 slides
EUR 262

Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala
T1236036Alz 5 slides
EUR 523

Paraffin Tissue Section - Alzheimers Disease: Brain: Precentral Gyrus (Movement)
T2236073Alz 5 slides
EUR 262

Paraffin Tissue Section - Alzheimers Disease: Brain: Postcentral Gyrus (Sensation)
T2236072Alz 5 slides
EUR 262

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)
MBS640174-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)
MBS640174-5x5Sections 5x5Sections
EUR 3170

Paraffin Tissue Section - Parkinson's Disease: Brain: Amygdala
T2236036Par 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Amygdala
T2236036Msc 5 slides
EUR 262

Tissue Section, Human Disease, Parkinson, Brain, Amygdala (Paraffin)
MBS640265-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain, Amygdala (Paraffin)
MBS640265-5x5Slides 5x5Slides
EUR 2145

Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum
T2236039Alz 5 slides
EUR 262

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)
MBS640539-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)
MBS640539-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Amygdala (Paraffin)
MBS639982-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Amygdala (Paraffin)
MBS639982-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)
MBS640521-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)
MBS640521-5x5Sections 5x5Sections
EUR 2145

Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata
T2236057Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)
MBS640323-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)
MBS640323-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)
MBS640497-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)
MBS640497-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)
MBS640635-5Sections 5Sections
EUR 985

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)
MBS640635-5x5Sections 5x5Sections
EUR 4280

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)
MBS640659-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Paraffin)
MBS640659-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)
MBS640226-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)
MBS640226-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)
MBS640156-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)
MBS640156-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)
MBS640705-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)
MBS640705-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)
MBS640034-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)
MBS640034-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)
MBS640442-5Slides 5Slides
EUR 725

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)
MBS640442-5x5Slides 5x5Slides
EUR 3100

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Paraffin)
MBS640774-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Paraffin)
MBS640774-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Paraffin)
MBS640745-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Paraffin)
MBS640745-5x5Sections 5x5Sections
EUR 2145

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala
MBS657576-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala
MBS657576-5x1mg 5x1mg
EUR 3470

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala
MBS639891-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Amygdala
MBS639891-5x01mg 5x0.1mg
EUR 2915

Paraffin Tissue Section - Human Adult Normal: Brain: Amygdala
T2234036 5 slides
EUR 363

Tissue, Section, Human Adult Normal, Brain, Amygdala (Paraffin)
MBS640169-5Sections 5Sections
EUR 590

Tissue, Section, Human Adult Normal, Brain, Amygdala (Paraffin)
MBS640169-5x5Sections 5x5Sections
EUR 2500

Frozen Tissue Section - Parkinson's Disease: Brain: Amygdala
T1236036Par 5 slides
EUR 523

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 8 different tissues
T8236444Alz 5 slides
EUR 713

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues
T8236445Alz 5 slides
EUR 713

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues
T8236564Alz 5 slides
EUR 713

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe
MBS639688-5Slides 5Slides
EUR 880

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe
MBS639688-5x5Slides 5x5Slides
EUR 3820

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues
T8236446Alz 5 slides
EUR 713

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Amygdala, BioGenomics
MBS652354-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Amygdala, BioGenomics
MBS652354-5x40Tests 5x40Tests
EUR 4250

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Amygdala, BioGenomics
MBS652517-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Amygdala, BioGenomics
MBS652517-5x40Tests 5x40Tests
EUR 4250

Tissue, Section, Human Disease, Parkinson, Brain, Amygdala (Frozen)
MBS640209-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Amygdala (Frozen)
MBS640209-5x5Slides 5x5Slides
EUR 3170

cDNA - Alzheimer's Disease: Brain: Amygdala
C1236036Alz 40 reactions
EUR 802

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Amygdala
T1236036Msc 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain
T1236035Alz 5 slides
EUR 523

Total Protein - Alzheimer's Disease: Brain: Amygdala
P1236036Alz 1 mg
EUR 542

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons
T1236071Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Amygdala (Frozen)
MBS640618-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Amygdala (Frozen)
MBS640618-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)
MBS640021-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)
MBS640021-5x5Slides 5x5Slides
EUR 3170

Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus
T1236079Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary
T1236068Alz 5 slides
EUR 971

Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum
T1236039Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Parietal Lobe
T1236066Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus
T1236052Alz 5 slides
EUR 971

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)
MBS640843-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)
MBS640843-5x5Sections 5x5Sections
EUR 3170

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640953-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640953-5x5Slides 5x5Slides
EUR 6190

Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe
T1236051Alz 5 slides
EUR 523

Paraffin Tissue Section - Parkinson's Disease: Brain
T2236035Par 5 slides
EUR 262

Frozen Tissue Section - Alzheimer's Disease: Brain: Temporal Lobe
T1236078Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Occipital Lobe
T1236062Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)
MBS640320-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)
MBS640320-5x5Sections 5x5Sections
EUR 3170

Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum
T1236045Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)
MBS640253-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)
MBS640253-5x5Sections 5x5Sections
EUR 3170

Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus
T1236073Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)
MBS640027-5Sections 5Sections
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)
MBS640027-5x5Sections 5x5Sections
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)
MBS640834-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)
MBS640834-5x5Slides 5x5Slides
EUR 3170

Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata
T1236057Alz 5 slides
EUR 523

Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus
T1236072Alz 5 slides
EUR 523

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)
MBS640297-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe (Frozen)
MBS640297-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)
MBS640325-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Frozen)
MBS640325-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)
MBS640199-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)
MBS640199-5x5Sections 5x5Sections
EUR 3170

Paraffin Tissue Section - Parkinson's Disease: Brain: Pons
T2236071Par 5 slides
EUR 262

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)
MBS639971-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)
MBS639971-5x5Slides 5x5Slides
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)
MBS640808-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)
MBS640808-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)
MBS640817-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)
MBS640817-5x5Slides 5x5Slides
EUR 3170

Paraffin Tissue Section - Parkinson's Disease: Brain: Thalamus
T2236079Par 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain
T2236035Msc 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Cerebellum
T2236039Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Hippocampus
T2236052Par 5 slides
EUR 834

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Frozen)
MBS640791-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Frozen)
MBS640791-5x5Sections 5x5Sections
EUR 3170

Paraffin Tissue Section - Parkinson's Disease: Brain: Frontal Lobe
T2236051Par 5 slides
EUR 262

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Frozen)
MBS640233-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Frozen)
MBS640233-5x5Sections 5x5Sections
EUR 3170

Tissue Section, Human Disease, Parkinson, Brain (Paraffin)
MBS640768-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain (Paraffin)
MBS640768-5x5Slides 5x5Slides
EUR 2145

Paraffin Tissue Section - Parkinson's Disease: Brain: Parietal Lobe
T2236066Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Temporal Lobe
T2236078Par 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Pons
T2236071Msc 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Occipital Lobe
T2236062Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Corpus Callosum
T2236045Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Precentral Gyrus
T2236073Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Medulla oblongata
T2236057Par 5 slides
EUR 262

Paraffin Tissue Section - Parkinson's Disease: Brain: Postcentral Gyrus
T2236072Par 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Thalamus
T2236079Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Cerebellum
T2236039Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus
T2236052Msc 5 slides
EUR 834

Tissue Section, Human Disease, Parkinson, Brain, Pons (Paraffin)
MBS640052-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain, Pons (Paraffin)
MBS640052-5x5Slides 5x5Slides
EUR 2145

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Frontal Lobe
T2236051Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Parietal Lobe
T2236066Msc 5 slides
EUR 262

Tissue, Section, Human Disease, Dementia, Brain, Thalamus (Paraffin)
MBS640773-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Dementia, Brain, Thalamus (Paraffin)
MBS640773-5x5Slides 5x5Slides
EUR 2145

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe
T2236062Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Temporal Lobe
T2236078Msc 5 slides
EUR 262

Tissue Section, Human Disease, Parkinson, Brain, Thalamus (Paraffin)
MBS640940-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain, Thalamus (Paraffin)
MBS640940-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Multiple Sclerosis, Brain (Paraffin)
MBS640003-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Multiple Sclerosis, Brain (Paraffin)
MBS640003-5x5Sections 5x5Sections
EUR 2145

Amygdala (Alzheimer's Disease) Lysate
XBL-10274 0.1 mg
EUR 796.2
Description: Human amygdala tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human amygdala tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the amygdala tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The amygdala tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue Section, Human Disease, Parkinson, Brain, Cerebellum (Paraffin)
MBS640375-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain, Cerebellum (Paraffin)
MBS640375-5x5Slides 5x5Slides
EUR 2145

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Corpus Callosum
T2236045Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Precentral Gyrus
T2236073Msc 5 slides
EUR 262

Tissue, Section, Human Disease, Depression, Brain, Thalamus (Paraffin)
MBS640110-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Depression, Brain, Thalamus (Paraffin)
MBS640110-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Paraffin)
MBS640722-5Slides 5Slides
EUR 985

Tissue, Section, Human Disease, Dementia, Brain, Hippocampus (Paraffin)
MBS640722-5x5Slides 5x5Slides
EUR 4280

Tissue Section, Human Disease, Parkinson, Brain, Hippocampus (Paraffin)
MBS640134-5Slides 5Slides
EUR 985

Tissue Section, Human Disease, Parkinson, Brain, Hippocampus (Paraffin)
MBS640134-5x5Slides 5x5Slides
EUR 4280

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Medulla oblongata
T2236057Msc 5 slides
EUR 262

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Postcentral Gyrus
T2236072Msc 5 slides
EUR 262

GSK3β inhibitory activity of compounds with pharmacological approach appears to be effective for treating the causes and symptoms of AD because they reduce neuroinflammation and pathological excellence in animal models of AD and provide relief from cognitive and neuropsychiatric symptoms. These compounds have the potential to be used as a drug for the treatment of AD, but their exact pharmacological, pharmacokinetic, toxicology and clinical profile needs to be defined.