Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer’s disease

Background: Studies have found that autophagy can promote clearance of Aβ. To promote and maintain the occurrence of autophagy in Alzheimer’s disease (AD) may be a potential way to reduce neuronal loss and improve learning and memory of AD.


Objective: To investigate the possible mechanism of Yishen Huazhuo Stew (YHD) for the model of AD.


Methods: Forty-seven-month-old male SAMP8 mice were randomly divided into the model (P8) YHD groups and groups, 20 in each group, with 20 SAMR1 rats as control (R1) group. All the mice were intragastric administered for 4 weeks, YHD at a dose of 6.24g / kg for YHD group, and distilled water to P8 groups and R1 group. Morris water maze (MWM) test, staining Nissl’s, TEM, TUNEL staining, immunofluorescence staining double, and western blot analysis were applied to learning and memory, structure and ultrastructure of neurons, autophagosome, the apoptotic index, Aβ, LAMP1, and autophagy-associated protein ,


Results: The escape latency time YHD group was significantly shorter in the 4 and 5 days for the test MWM than P8 group (P = 0.011, 0.008 <0.05), and the number of crossing platform in YHD group increased significantly (P = 0, 02 <0.05). Nissl staining showed that the number of neurons in YHD group increased significantly (P <0.0001). TEM shows in YHD group, the nucleus of neurons slightly irregular, with slightly reduced organelles, partially fused and blurred crest and the mitochondrial membrane.

YHD group apoptosis index showed a downward trend, with no statistically significant difference (P = 0.093> 0.05), whereas the expression Caspase3 YHD group was significantly lower (P = 0.044 <0.05). YHD can promote clearance of Aβ1-42 protein, upregulated Beclin-1 and p-Bcl-2 protein, reducing the protein mTOR and P62.


Conclusion: YHD can induce autophagy initiation, increasing the formation of autophagosomes and autolysosome, promoting autophagy substrate degradation, so as to regulate autophagy, so as to promote the clearance of Aβ1-42 to improve SAMP8 memory impairment in mice.

Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer's disease
Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer’s disease

White Matter Brain Research Network in Alzheimer’s Disease Using Persistent Features

Despite the severe social burden caused by Alzheimer’s disease (AD), there is no drug on the can change the progression of the disease have been identified yet. Structural brain tissue research provides an opportunity to understand the physiological damage caused by AD and its precursor, mild cognitive impairment (MCI). More recently, persistent homology has been used to study the brain network dynamics and characteristics of the global network organization.

However, it is not clear how these parameters reflect structural changes in the brain tissue of patients with AD or MCI. In this study, we proposed earlier persistent features and various measures traditionally used graph theory to measure the topological properties of white matter (WM) network in 150 subjects with diffusion tensor imaging (DTI). We found no significant difference in these measures between AD, MCI and normal controls (NC) under different brain partitioning scheme.

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)
MBS640199-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Frozen)
MBS640199-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)
MBS640253-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Frozen)
MBS640253-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)
MBS640021-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Frozen)
MBS640021-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Dementia, Brain, Frontal Lobe (Frozen)
MBS640371-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Dementia, Brain, Frontal Lobe (Frozen)
MBS640371-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Parkinson, Brain, Frontal Lobe (Frozen)
MBS640041-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Frontal Lobe (Frozen)
MBS640041-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)
MBS640843-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Frozen)
MBS640843-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Depression, Brain, Frontal Lobe (Frozen)
MBS640212-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Depression, Brain, Frontal Lobe (Frozen)
MBS640212-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe
MBS657343-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Frontal Lobe
MBS657343-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)
MBS640174-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Frozen)
MBS640174-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)
MBS640320-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Frozen)
MBS640320-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)
MBS640027-5Sections 5Sections
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Frozen)
MBS640027-5x5Sections 5x5Sections
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)
MBS640834-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Frozen)
MBS640834-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Frontal Lobe (Frozen)
MBS640348-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Frontal Lobe (Frozen)
MBS640348-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)
MBS639971-5Slides 5Slides
EUR 1195

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pituitary Gland (Frozen)
MBS639971-5x5Slides 5x5Slides
EUR 5155

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)
MBS640808-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Frozen)
MBS640808-5x5Sections 5x5Sections
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)
MBS640817-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Frozen)
MBS640817-5x5Slides 5x5Slides
EUR 3170

cDNA - Alzheimer's Disease: Brain: Frontal Lobe
C1236051Alz 40 reactions
EUR 600.6

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Frontal Lobe, BioGenomics
MBS654365-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Frontal Lobe, BioGenomics
MBS654365-5x005mg 5x0.05mg
EUR 3075

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Frozen)
MBS640791-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Frozen)
MBS640791-5x5Sections 5x5Sections
EUR 3170

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue II, Corpus Callosum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Pons, Temporal Lobe, Thalamus
MBS640559-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue II, Corpus Callosum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Pons, Temporal Lobe, Thalamus
MBS640559-5x5Slides 5x5Slides
EUR 6190

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Frontal Lobe (Frozen)
MBS640245-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Frontal Lobe (Frozen)
MBS640245-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Frozen)
MBS640233-5Sections 5Sections
EUR 755

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Frozen)
MBS640233-5x5Sections 5x5Sections
EUR 3170

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Frontal Lobe, BioGenomics
MBS652378-40Tests 40Tests
EUR 995

Tissue cDNA, First Strand, Human Diseased, Alzheimer's Disease, Brain, Frontal Lobe, BioGenomics
MBS652378-5x40Tests 5x40Tests
EUR 4250

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640953-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue I, Amygdala, Frontal Lobe, Hippocampus, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640953-5x5Slides 5x5Slides
EUR 6190

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue IV, Cerebellum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640057-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue IV, Cerebellum, Frontal Lobe, Occipital Lobe, Parietal Lobe, Postcentral Gyrus, Precentral Gyrus, Temporal Lobe
MBS640057-5x5Slides 5x5Slides
EUR 6190

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)
MBS640156-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Occipital Lobe (Paraffin)
MBS640156-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)
MBS640226-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe (Paraffin)
MBS640226-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)
MBS640705-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe (Paraffin)
MBS640705-5x5Sections 5x5Sections
EUR 2145

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Frontal Lobe, BioGenomics
MBS638632-001mg 0.01mg
EUR 655

Tissue, Total RNA, Human Disease, Alzheimer's Disease, Frontal Lobe, BioGenomics
MBS638632-5x001mg 5x0.01mg
EUR 2735

Genomic DNA - Alzheimer's Disease: Brain: Frontal Lobe, from a single donor
D1236051Alz 50 ug
EUR 420.7

Frontal Lobe (Alzheimer's Disease) Lysate
XBL-10282 0.1 mg
EUR 796.2
Description: Human frontal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human frontal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the frontal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The frontal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Tissue, Section, Human Disease, Dementia, Brain, Frontal Lobe (Paraffin)
MBS640546-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Dementia, Brain, Frontal Lobe (Paraffin)
MBS640546-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Adult Normal, Brain, Frontal Lobe (Frozen)
MBS640144-5Sections 5Sections
EUR 635

Tissue, Section, Human Adult Normal, Brain, Frontal Lobe (Frozen)
MBS640144-5x5Sections 5x5Sections
EUR 2640

Tissue Section, Human Disease, Parkinson, Brain, Frontal Lobe (Paraffin)
MBS640148-5Slides 5Slides
EUR 510

Tissue Section, Human Disease, Parkinson, Brain, Frontal Lobe (Paraffin)
MBS640148-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Depression, Brain, Frontal Lobe (Paraffin)
MBS640797-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Depression, Brain, Frontal Lobe (Paraffin)
MBS640797-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)
MBS640539-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain (Paraffin)
MBS640539-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Frontal Lobe (Paraffin)
MBS640366-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Frontal Lobe (Paraffin)
MBS640366-5x5Slides 5x5Slides
EUR 2145

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue II, frontal lobe, temporal lobe, parietal lobe, occipital lobe, pons, thalamus, corpus callosum
MBS639675-5Arrays 5Arrays
EUR 880

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue II, frontal lobe, temporal lobe, parietal lobe, occipital lobe, pons, thalamus, corpus callosum
MBS639675-5x5Arrays 5x5Arrays
EUR 3820

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)
MBS640521-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Pons (Paraffin)
MBS640521-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)
MBS640882-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Amygdala (Paraffin)
MBS640882-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)
MBS640323-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Thalamus (Paraffin)
MBS640323-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)
MBS640497-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Cerebellum (Paraffin)
MBS640497-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)
MBS640635-5Sections 5Sections
EUR 985

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Hippocampus (Paraffin)
MBS640635-5x5Sections 5x5Sections
EUR 4280

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue IV, Precentral gyrus, postcentral gyrus, frontal lobe, temporal lobe, parietal lobe, occipital lobe, cerebellum
MBS639485-5Arrays 5Arrays
EUR 880

Tissue, Array, Human Disease, Alzheimer's Disease, Multi, tissue IV, Precentral gyrus, postcentral gyrus, frontal lobe, temporal lobe, parietal lobe, occipital lobe, cerebellum
MBS639485-5x5Arrays 5x5Arrays
EUR 3820

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Frontal Lobe (Paraffin)
MBS640149-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Frontal Lobe (Paraffin)
MBS640149-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)
MBS640034-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Corpus Callosum (Paraffin)
MBS640034-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)
MBS640442-5Slides 5Slides
EUR 725

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Medulla Oblongata (Paraffin)
MBS640442-5x5Slides 5x5Slides
EUR 3100

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Paraffin)
MBS640774-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Precentral Gyrus (Movement) (Paraffin)
MBS640774-5x5Sections 5x5Sections
EUR 2145

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe
MBS639688-5Slides 5Slides
EUR 880

Tissue Panel (Paraffin), Human Disease, Alzheimer's Disease, Paraffin, Multi- tissue I: Frontal lobe, Temporal lobe, Hippocampus, Amygdala, Precentral gyrus, Postcentral gyrus, Occipital lobe
MBS639688-5x5Slides 5x5Slides
EUR 3820

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Paraffin)
MBS640745-5Sections 5Sections
EUR 510

Tissue, Section, Human Disease, Alzheimer's Disease, Brain, Postcentral Gyrus (Sensation) (Paraffin)
MBS640745-5x5Sections 5x5Sections
EUR 2145

Tissue, Section, Human Disease, Dementia, Brain, Temporal Lobe (Frozen)
MBS640402-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Dementia, Brain, Temporal Lobe (Frozen)
MBS640402-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Dementia, Brain, Parietal Lobe (Frozen)
MBS640813-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Dementia, Brain, Parietal Lobe (Frozen)
MBS640813-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Dementia, Brain, Occipital Lobe (Frozen)
MBS640930-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Dementia, Brain, Occipital Lobe (Frozen)
MBS640930-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Parkinson, Brain, Parietal Lobe (Frozen)
MBS640203-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Parietal Lobe (Frozen)
MBS640203-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Parkinson, Brain, Temporal Lobe (Frozen)
MBS640694-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Temporal Lobe (Frozen)
MBS640694-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Depression, Brain, Parietal Lobe (Frozen)
MBS640396-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Depression, Brain, Parietal Lobe (Frozen)
MBS640396-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Depression, Brain, Temporal Lobe (Frozen)
MBS640403-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Depression, Brain, Temporal Lobe (Frozen)
MBS640403-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Parkinson, Brain, Occipital Lobe (Frozen)
MBS640287-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Occipital Lobe (Frozen)
MBS640287-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Depression, Brain, Occipital Lobe (Frozen)
MBS640358-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Depression, Brain, Occipital Lobe (Frozen)
MBS640358-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Temporal Lobe (Frozen)
MBS640614-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Temporal Lobe (Frozen)
MBS640614-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Parietal Lobe (Frozen)
MBS640701-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Parietal Lobe (Frozen)
MBS640701-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Occipital Lobe (Frozen)
MBS640083-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Multiple Sclerosis, Brain, Occipital Lobe (Frozen)
MBS640083-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe
MBS657032-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe
MBS657032-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe
MBS657046-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Parietal Lobe
MBS657046-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe
MBS657066-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Alzheimer's Disease, Brain, Occipital lobe
MBS657066-5x1mg 5x1mg
EUR 3470

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe
MBS639875-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Alzheimer's Disease, Brain, Temporal Lobe
MBS639875-5x01mg 5x0.1mg
EUR 2915

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Occipital Lobe (Frozen)
MBS640055-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Occipital Lobe (Frozen)
MBS640055-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Parietal Lobe (Frozen)
MBS640947-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Parietal Lobe (Frozen)
MBS640947-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Temporal Lobe (Frozen)
MBS640408-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Progressive Supranuclear Palsy, Brain, Temporal Lobe (Frozen)
MBS640408-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Adult Normal, Brain, Frontal Lobe (Paraffin)
MBS640428-5Sections 5Sections
EUR 460

Tissue, Section, Human Adult Normal, Brain, Frontal Lobe (Paraffin)
MBS640428-5x5Sections 5x5Sections
EUR 1925

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue III, Cerebellum, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus
MBS640114-5Slides 5Slides
EUR 1425

Tissue, Section Panel, Human Disease, Alzheimer's Disease, Multi-Tissue III, Cerebellum, Occipital Lobe, Postcentral Gyrus, Precentral Gyrus
MBS640114-5x5Slides 5x5Slides
EUR 6190

Tissue, Section, Human Disease, Diabetes, Brain (Frozen)
MBS640760-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Brain (Frozen)
MBS640760-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Parkinson, Brain (Frozen)
MBS639962-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain (Frozen)
MBS639962-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Parkinson's Disease, Brain, Frontal Lobe
MBS657030-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Parkinson's Disease, Brain, Frontal Lobe
MBS657030-5x1mg 5x1mg
EUR 3470

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Temporal Lobe, BioGenomics
MBS654349-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Temporal Lobe, BioGenomics
MBS654349-5x005mg 5x0.05mg
EUR 3075

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Parietal Lobe, BioGenomics
MBS654640-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Parietal Lobe, BioGenomics
MBS654640-5x005mg 5x0.05mg
EUR 3075

Frozen-Tissue-Section---Alzheimer's-Disease:-Brain:-Frontal-Lobe
T1236051Alz 5 slides
EUR 391.65

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Occipital Lobe, BioGenomics
MBS654667-005mg 0.05mg
EUR 715

Tissue, Genomic DNA, Human Disease (Adult), Alzheimer's Disease, Brain, Occipital Lobe, BioGenomics
MBS654667-5x005mg 5x0.05mg
EUR 3075

Tissue, Total Protein, Human Disease, Dementia, Brain, Frontal Lobe
MBS657393-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Dementia, Brain, Frontal Lobe
MBS657393-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Depression, Brain, Frontal Lobe
MBS657117-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Depression, Brain, Frontal Lobe
MBS657117-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Parkinson, Brain, Pons (Frozen)
MBS640054-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Parkinson, Brain, Pons (Frozen)
MBS640054-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Multiple Sclerosis, Brain (Frozen)
MBS639775-5Slides 5Slides
EUR 755

network integration decreased and increased network separation expressed in AD and MCI. In addition, measures of persistent homology-based show statistically stronger capability and durability of the actions graph-traditional theory, suggesting that they represent a more sensitive approach to detect structural brain changes and to better understand AD symptomology at the network level. These findings contribute to an increased understanding of the structural connectome in AD and provide a new approach to potentially track the development of AD.