Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer’s disease

Background: Studies have found that autophagy can promote clearance of Aβ. To promote and maintain the occurrence of autophagy in Alzheimer’s disease (AD) may be a potential way to reduce neuronal loss and improve learning and memory of AD.


Objective: To investigate the possible mechanism of Yishen Huazhuo Stew (YHD) for the model of AD.


Methods: Forty-seven-month-old male SAMP8 mice were randomly divided into the model (P8) YHD groups and groups, 20 in each group, with 20 SAMR1 rats as control (R1) group. All the mice were intragastric administered for 4 weeks, YHD at a dose of 6.24g / kg for YHD group, and distilled water to P8 groups and R1 group. Morris water maze (MWM) test, staining Nissl’s, TEM, TUNEL staining, immunofluorescence staining double, and western blot analysis were applied to learning and memory, structure and ultrastructure of neurons, autophagosome, the apoptotic index, Aβ, LAMP1, and autophagy-associated protein ,


Results: The escape latency time YHD group was significantly shorter in the 4 and 5 days for the test MWM than P8 group (P = 0.011, 0.008 <0.05), and the number of crossing platform in YHD group increased significantly (P = 0, 02 <0.05). Nissl staining showed that the number of neurons in YHD group increased significantly (P <0.0001). TEM shows in YHD group, the nucleus of neurons slightly irregular, with slightly reduced organelles, partially fused and blurred crest and the mitochondrial membrane.

YHD group apoptosis index showed a downward trend, with no statistically significant difference (P = 0.093> 0.05), whereas the expression Caspase3 YHD group was significantly lower (P = 0.044 <0.05). YHD can promote clearance of Aβ1-42 protein, upregulated Beclin-1 and p-Bcl-2 protein, reducing the protein mTOR and P62.


Conclusion: YHD can induce autophagy initiation, increasing the formation of autophagosomes and autolysosome, promoting autophagy substrate degradation, so as to regulate autophagy, so as to promote the clearance of Aβ1-42 to improve SAMP8 memory impairment in mice.

 Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer's disease
Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer’s disease

White Matter Brain Research Network in Alzheimer’s Disease Using Persistent Features

Despite the severe social burden caused by Alzheimer’s disease (AD), there is no drug on the can change the progression of the disease have been identified yet. Structural brain tissue research provides an opportunity to understand the physiological damage caused by AD and its precursor, mild cognitive impairment (MCI). More recently, persistent homology has been used to study the brain network dynamics and characteristics of the global network organization.

However, it is not clear how these parameters reflect structural changes in the brain tissue of patients with AD or MCI. In this study, we proposed earlier persistent features and various measures traditionally used graph theory to measure the topological properties of white matter (WM) network in 150 subjects with diffusion tensor imaging (DTI). We found no significant difference in these measures between AD, MCI and normal controls (NC) under different brain partitioning scheme.

Frozen Tissue Section - Alzheimer's Disease: Brain: Pons

T1236071Alz 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Frontal Lobe

T1236051Par 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala

T1236036Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus

T1236079Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary

T1236068Alz 5 slides
EUR 883

Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T1236039Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus

T1236052Alz 5 slides
EUR 883

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Frontal Lobe

T1236051Msc 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Corpus Callosum

T1236045Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Precentral Gyrus

T1236073Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T1236057Alz 5 slides
EUR 475

Frozen Tissue Section - Alzheimer's Disease: Brain: Postcentral Gyrus

T1236072Alz 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Frontal Lobe

C1236051Alz 40 reactions
EUR 729

Total Protein - Alzheimer's Disease: Brain: Frontal Lobe

P1236051Alz 1 mg
EUR 471

Frozen Tissue Section - Dementia: Brain: Frontal Lobe

T1236051Dem 5 slides
EUR 475

Frozen Tissue Section - Depression: Brain: Frontal Lobe

T1236051Dep 5 slides
EUR 475

Genomic DNA - Alzheimer's Disease: Brain: Frontal Lobe, from a single donor

D1236051Alz 50 ug
EUR 489

Frontal Lobe (Alzheimer's Disease) Lysate

XBL-10282 0.1 mg
EUR 796.2
Description: Human frontal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human frontal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the frontal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The frontal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Paraffin Tissue Section - Parkinson's Disease: Brain: Frontal Lobe

T2236051Par 5 slides
EUR 238

Total RNA - Alzheimer's Disease: Frontal Lobe

R1236051Alz-10 10 ug
EUR 421.2

Frozen Tissue Section - Human Adult Normal: Brain: Frontal Lobe

T1234051 5 slides
EUR 343

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Frontal Lobe

T2236051Msc 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Parietal Lobe

T2236066Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Temporal Lobe

T2236078Alz 5 slides
EUR 238

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 7 different tissues

T6236444Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T6236445Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T6236446Alz 5 slides
EUR 1135

Frozen Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T6236564Alz 5 slides
EUR 1135

Paraffin Tissue Section - Alzheimers Disease: Brain: Occipital Lobe

T2236062Alz 5 slides
EUR 238

Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Frontal Lobe

T1236051PSP 5 slides
EUR 475

Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum

T2236039Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimer's Disease: Brain: Medulla oblongata

T2236057Alz 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Parietal Lobe

T1236066Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Temporal Lobe

T1236078Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T1236062Par 5 slides
EUR 475

Paraffin Tissue Section - Alzheimers Disease: Brain

T2236035Alz 5 slides
EUR 238

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe

T1236062Msc 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Parietal Lobe

T1236066Msc 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Temporal Lobe

T1236078Msc 5 slides
EUR 475

Paraffin Tissue Section - Alzheimers Disease: Brain: Pons

T2236071Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Amygdala

T2236036Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus

T2236079Alz 5 slides
EUR 238

Paraffin Tissue Section - Alzheimers Disease: Brain: Hippocampus

T2236052Alz 5 slides
EUR 758

Frozen Tissue Section - Parkinson's Disease: Brain

T1236035Par 5 slides
EUR 475

Paraffin Tissue Section - Alzheimers Disease: Brain: Corpus Callosum

T2236045Alz 5 slides
EUR 238

Paraffin Tissue Section - Dementia: Brain: Frontal Lobe

T2236051Dem 5 slides
EUR 238

Paraffin Tissue Section - Depression: Brain: Frontal Lobe

T2236051Dep 5 slides
EUR 238

Frozen Tissue Section - Parkinson's Disease: Brain: Pons

T1236071Par 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain

T1236035Msc 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Amygdala

T1236036Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Thalamus

T1236079Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Pituitary

T1236068Par 5 slides
EUR 883

Paraffin Tissue Section - Alzheimers Disease: Brain: Precentral Gyrus (Movement)

T2236073Alz 5 slides
EUR 238

Frozen Tissue Section - Parkinson's Disease: Brain: Cerebellum

T1236039Par 5 slides
EUR 475

Paraffin Tissue Section - Alzheimers Disease: Brain: Postcentral Gyrus (Sensation)

T2236072Alz 5 slides
EUR 238

Paraffin Tissue Section - Human Adult Normal: Brain: Frontal Lobe

T2234051 5 slides
EUR 185

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Pons

T1236071Msc 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Corpus Callosum

T1236045Par 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Precentral Gyrus

T1236073Par 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Parietal Lobe

C1236066Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Temporal Lobe

C1236078Alz 40 reactions
EUR 729

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Amygdala

T1236036Msc 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain: Medulla oblongata

T1236057Par 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Pituitary

T1236068Msc 5 slides
EUR 883

Frozen Tissue Section - Parkinson's Disease: Brain: Postcentral Gyrus

T1236072Par 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Thalamus

T1236079Msc 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Occipital Lobe

C1236062Alz 40 reactions
EUR 729

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Cerebellum

T1236039Msc 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus

T1236052Msc 5 slides
EUR 883

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue I, 8 different tissues

T8236444Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue II, 7 different tissues

T8236445Alz 5 slides
EUR 648

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue IV, 7 different tissues

T8236564Alz 5 slides
EUR 648

Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Frontal Lobe

T2236051PSP 5 slides
EUR 238

Paraffin Tissue Section Panel - Human Disease Tissue, Alzheimer's Disease, Multi-tissue III, 8 different tissues

T8236446Alz 5 slides
EUR 648

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Corpus Callosum

T1236045Msc 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Precentral Gyrus

T1236073Msc 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Brain

T1236035Dia 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Medulla oblongata

T1236057Msc 5 slides
EUR 475

Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Postcentral Gyrus

T1236072Msc 5 slides
EUR 475

Total Protein - Alzheimer's Disease: Brain: Parietal Lobe

P1236066Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Temporal Lobe

P1236078Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Occipital Lobe

P1236062Alz 1 mg
EUR 471

Frozen Tissue Section - Dementia: Brain: Parietal Lobe

T1236066Dem 5 slides
EUR 475

Frozen Tissue Section - Dementia: Brain: Temporal Lobe

T1236078Dem 5 slides
EUR 475

Frozen Tissue Section - Dementia: Brain: Occipital Lobe

T1236062Dem 5 slides
EUR 475

Frozen Tissue Section - Depression: Brain: Parietal Lobe

T1236066Dep 5 slides
EUR 475

Frozen Tissue Section - Depression: Brain: Temporal Lobe

T1236078Dep 5 slides
EUR 475

Frozen Tissue Section - Depression: Brain: Occipital Lobe

T1236062Dep 5 slides
EUR 475

Genomic DNA - Alzheimer's Disease: Brain: Parietal Lobe, from a single donor

D1236066Alz 50 ug
EUR 489

Genomic DNA - Alzheimer's Disease: Brain: Temporal Lobe, from a single donor

D1236078Alz 50 ug
EUR 489

Paraffin Tissue Section - Human Normal: Brain – Frontal Lobe, 10x Visium-Characterized

T2234051-SV 1 slide
EUR 524

Genomic DNA - Alzheimer's Disease: Brain: Occipital Lobe, from a single donor

D1236062Alz 50 ug
EUR 489

Total Protein - Parkinson's Disease: Brain: Frontal Lobe

P1236051Par 1 mg
EUR 471

Frozen Tissue Section - Human Adult Normal: Brain: Parietal Lobe

T1234066 5 slides
EUR 343

Frozen Tissue Section - Human Adult Normal: Brain: Temporal Lobe

T1234078 5 slides
EUR 343

Frozen Tissue Section - Human Adult Normal: Brain: Occipital Lobe

T1234062 5 slides
EUR 343

cDNA - Alzheimer's Disease: Brain

C1236035Alz 40 reactions
EUR 729

Frozen Tissue Section - Congenital heart disease: Heart

T1236122Hd-3 5 slides
EUR 475

Total Protein - Multiple Sclerosis Disease: Brain: Frontal Lobe

P1236051Msc 1 mg
EUR 471

Paraffin Tissue Section - Parkinson's Disease: Brain: Parietal Lobe

T2236066Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Temporal Lobe

T2236078Par 5 slides
EUR 238

Paraffin Tissue Section - Parkinson's Disease: Brain: Occipital Lobe

T2236062Par 5 slides
EUR 238

Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Occipital Lobe

T1236062PSP 5 slides
EUR 475

Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Parietal Lobe

T1236066PSP 5 slides
EUR 475

Frozen Tissue Section - Progressive Supranuclear Palsy: Brain: Temporal Lobe

T1236078PSP 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Pons

C1236071Alz 40 reactions
EUR 729

Total RNA - Alzheimer's Disease: Brain

R1236035Alz-50 50 ug
EUR 421.2

Parietal Lobe (Alzheimer's Disease) Lysate

XBL-10294 0.1 mg
EUR 796.2
Description: Human parietal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human parietal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the parietal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The parietal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Temporal Lobe (Alzheimer's Disease) Lysate

XBL-10314 0.1 mg
EUR 796.2
Description: Human temporal lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human temporal lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the temporal lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The temporal lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Occipital lobe (Alzheimer's Disease) Lysate

XBL-10290 0.1 mg
EUR 796.2
Description: Human occipital lobe tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human occipital lobe tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the occipital lobe tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The occipital lobe tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

cDNA - Alzheimer's Disease: Brain: Amygdala

C1236036Alz 40 reactions
EUR 729

cDNA - Alzheimer's Disease: Brain: Thalamus

C1236079Alz 40 reactions
EUR 729

Total Protein - Alzheimer's Disease: Brain

P1236035Alz 1 mg
EUR 471

Genomic DNA - Alzheimer's Disease: Brain, from a single donor

D1236035Alz 50 ug
EUR 489

Genomic DNA - Parkinson's Disease: Brain: Frontal Lobe, from a single donor

D1236051Par 50 ug
EUR 489

cDNA - Alzheimer's Disease: Brain: Cerebellum

C1236039Alz 40 reactions
EUR 729

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Occipital Lobe

T2236062Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Parietal Lobe

T2236066Msc 5 slides
EUR 238

Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Temporal Lobe

T2236078Msc 5 slides
EUR 238

cDNA - Alzheimer's Disease: Brain: Hippocampus

C1236052Alz 40 reactions
EUR 886

Membrane Protein - Alzheimer's Disease:Brain: Temporal Lobe

P3236078Alz 0.1 mg
EUR 410

Total RNA - Alzheimer's Disease: Parietal Lobe

R1236066Alz-10 10 ug
EUR 421.2

Total RNA - Alzheimer's Disease: Temporal Lobe

R1236078Alz-10 10 ug
EUR 421.2

Total RNA - Alzheimer's Disease: Occipital Lobe

R1236062Alz-10 10 ug
EUR 421.2

Frozen Tissue Section - Human Diabetic Diseased Tissue: Eye

T1236108Dia 5 slides
EUR 662

Human Brain Frontal Lobe Fetal Tissue Lysate

IHUBRFLBFSTL100UG each
EUR 541
Description: Human Brain Frontal Lobe Fetal Tissue Lysate

Frozen Tissue Section - Human Diabetic Diseased Tissue: Lung

T1236152Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin

T1236218Dia 5 slides
EUR 475

Total Protein - Alzheimer's Disease: Brain: Pons

P1236071Alz 1 mg
EUR 471

Frozen Tissue Section - Human Tumor: Brain

T1235035 5 slides
EUR 330

Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon

T1236090Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Heart

T1236122Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Liver

T1236149Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Kidney

T1236142Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Spleen

T1236246Dia 5 slides
EUR 475

Genomic DNA - Alzheimer's Disease: Brain: Pons, from a single donor

D1236071Alz 50 ug
EUR 489

Genomic DNA - Multiple Sclerosis Disease: Brain: Frontal Lobe, from a single donor

D1236051Msc 50 ug
EUR 489

Temporal Lobe (Alzheimer's Disease) Membrane Lysate

XBL-10312 0.1 mg
EUR 752.1
Description: Human brain temporal lobe tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human temporal lobe tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated brain temporal lobe tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated brain temporal lobe tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Frozen Tissue Section - Human Diabetic Diseased Tissue: Adrenal

T1236004Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Stomach

T1236248Dia 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Precentral Gyrus

C1236073Alz 40 reactions
EUR 729

Frozen Tissue Section - Human Diabetic Diseased Tissue: Pancreas

T1236188Dia 5 slides
EUR 475

cDNA - Alzheimer's Disease: Brain: Postcentral Gyrus

C1236072Alz 40 reactions
EUR 729

Total Protein - Alzheimer's Disease: Brain: Amygdala

P1236036Alz 1 mg
EUR 471

Total Protein - Alzheimer's Disease: Brain: Thalamus

P1236079Alz 1 mg
EUR 471

Frozen Tissue Section - Human Diabetic Diseased Tissue: Esophagus

T1236106Dia 5 slides
EUR 475

Total Protein - Alzheimer's Disease: Brain: Cerebellum

P1236039Alz 1 mg
EUR 471

Genomic DNA - Alzheimer's Disease: Brain: Thalamus, from a single donor

D1236079Alz 50 ug
EUR 489

Total Protein - Alzheimer's Disease: Brain: Hippocampus

P1236052Alz 1 mg
EUR 580

Frozen Tissue Section - Dementia: Brain: Thalamus

T1236079Dem 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow

T1236024Dia 5 slides
EUR 662

Genomic DNA - Alzheimer's Disease: Brain: Cerebellum, from a single donor

D1236039Alz 50 ug
EUR 489

Frozen Tissue Section - Depression: Brain: Thalamus

T1236079Dep 5 slides
EUR 475

Frozen Tissue Section - Dementia: Brain: Hippocampus

T1236052Dem 5 slides
EUR 883

Frozen Tissue Section - Human Adult Normal: Brain

T1234035 5 slides
EUR 343

Frozen Tissue Section - Human Diabetic Diseased Tissue: Visceral Adipose

T1236003VisDia 5 slides
EUR 662

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle

T1236171Dia 5 slides
EUR 475

Frozen Tissue Section - Depression: Brain: Hippocampus

T1236052Dep 5 slides
EUR 883

Frozen Tissue Section - Human Adult Normal: Brain: Brain Stem

T1234075 5 slides
EUR 343

network integration decreased and increased network separation expressed in AD and MCI. In addition, measures of persistent homology-based show statistically stronger capability and durability of the actions graph-traditional theory, suggesting that they represent a more sensitive approach to detect structural brain changes and to better understand AD symptomology at the network level. These findings contribute to an increased understanding of the structural connectome in AD and provide a new approach to potentially track the development of AD.